FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00856-9
Abstract: Since microglia-associated neuroinflammation plays a pivotal role in the progression of white matter diseases, modulating microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of fingolimod (FTY720) on… read more here.
Keywords: anti inflammatory; fty720; via stat1; autophagy via ... See more keywords
FTY720 induces neutrophil extracellular traps via a NADPH oxidase-independent pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.109015
Abstract: FTY720 is an immunosuppressive agent which has been approved to treat multiple sclerosis (MS). The main object of the present study is to investigate whether FTY720 has the potential to induce the formation of neutrophil… read more here.
Keywords: neutrophil extracellular; fty720; formation; nadph oxidase ... See more keywords
FTY720 in CNS injuries: Molecular mechanisms and therapeutic potential
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.08.013
Abstract: Central nervous system (CNS) injuries, such as traumatic brain injury (TBI), subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), are important causes of disability and death worldwide. FTY720, a structural sphingosine analog and sphingosine-1-phosphate receptor (S1PR)… read more here.
Keywords: fty720 cns; fty720; injuries molecular; cns injuries ... See more keywords
Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.01.012
Abstract: Aims: To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism. Main methods: As an animal model of autism, we used intraperitoneal injection of VPA on embryonic day 12.5 in… read more here.
Keywords: model autism; memory; learning memory; fty720 ... See more keywords
FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107701
Abstract: Multiple system atrophy (MSA) is a fatal demyelinating disorder lacking any disease-modifying therapies. MSA pathology stems from aggregated α-synuclein (aSyn) accumulation in glial cytosolic inclusions of oligodendroglial cell (OLGs), the myelinating cells of brain. In… read more here.
Keywords: cell; fty720; expression; factor ... See more keywords
Beneficial Effects of Fingolimod on Social Interaction, CNS and Peripheral Immune Response in the BTBR Mouse Model of Autism
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.03.041
Abstract: Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by social communication deficits and repetitive/stereotyped behaviours. We evaluated the effects of a chronic treatment with the immunomodulator drug Fingolimod (FTY720 - a non-selective Sphingosine 1-Phosphate Receptor… read more here.
Keywords: fty720; btbr; autism; model ... See more keywords
FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06047-9
Abstract: In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of the OSCC cell lines SCC4, SCC25, and… read more here.
Keywords: fty720 induced; reactive oxygen; oxygen species; apoptosis ... See more keywords
Fingolimod inhibits proliferation and epithelial–mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200221
Abstract: Abstract Purpose: To explore the sensitivity of the immunosuppressive agent fingolimod (FTY720) in chordoma and determine whether it can serve as an appropriate alternate treatment for unresectable tumours in patients after incomplete surgery. Methods: Cell… read more here.
Keywords: stat3 signalling; chordoma; sacral chordoma; epithelial mesenchymal ... See more keywords
FTY720 hinders IFN-γ-mediated fibrotic scar formation and facilitates neurological recovery after spinal cord injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0387
Abstract: Following spinal cord injury (SCI), fibrotic scar inhibits axon regeneration and impairs neurological function recovery. It has been reported that T cell-derived IFN-γ plays a pivotal role in promoting fibrotic scarring in neurodegenerative disease. However,… read more here.
Keywords: fibrotic scar; fty720; scar formation; spinal cord ... See more keywords
A13768 Long term FTY720 treatment induced renal arteriole endothelial injury in deoxycorticosterone acetate (DOCA)/salt hypertensive rat
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548296.01877.d9
Abstract: Objectives: The sphingosine-1-phosphate (S1P) receptor modulator FTY720 exerts pleiotropic effects on the cardiovascular system. We examined the effects of long term FTY720 treatment on mineralocorticoid/salt-induced renal injury. Methods: Uninephrectomized rats on 0.9% NaCl/0.3% KCl drinking… read more here.
Keywords: fty720; doca fty720; doca; fty720 group ... See more keywords
Abstract A83: In vitro and In vivo antitumor activity of immune suppressant FTY720
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a83
Abstract: Purpose: Sphingosine-1-phosphate (S1P) is a pleotropic bioactive lipid mediator involved in the pathogenesis of inflammation and cancer. FTY720 is a “functional antagonist” of S1P by binding and induces the internalization and degradation of S1P receptors.… read more here.
Keywords: antitumor activity; cancer; activity; tumor ... See more keywords