In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.
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DOI: 10.1016/j.ejmech.2018.09.043
Abstract: A series of compounds containing pyrrolidine and pyrrolizidine cores with appended hydrophobic substituents were prepared as constrained analogs of FTY720 and phytosphingosine. The effect of these compounds on the viability of cancer cells, on downregulation… read more here.
Keywords: analogs dual; phytosphingosine analogs; fty720 phytosphingosine; dual acting ... See more keywords