Development of a UHPLC-MS method for inhibitor screening against α-L-1,3-fucosidase
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01575-x
Abstract: Abstractα-L-Fucosidase (AFU) is a promising therapeutic target for the treatment of inflammation, cancer, cystic fibrosis, and fucosidosis. Some of the existing analytical methods for the assessment of AFU activity are lacking in sensitivity and selectivity,… read more here.
Keywords: fucosidase; method; inhibitor screening; uhplc method ... See more keywords
Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8943-x
Abstract: Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its… read more here.
Keywords: plasma; autoimmune; fucosidase; pediatric cohort ... See more keywords
Kinetic and biophysical characterization of a lysosomal α-l-fucosidase from the fresh water mussel, Lamellidens corrianus.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.06.050
Abstract: Kinetic and biophysical studies have been carried out on a lysosomal α-l-fucosidase purified from the fresh water mussel, Lamellidens corrianus. The enzyme migrates as a single band in SDS-PAGE as well as native PAGE corresponding… read more here.
Keywords: mussel lamellidens; fucosidase; water mussel; kinetic biophysical ... See more keywords
Epididymal α-l-fucosidase and its possible role in remodelling the surface of bull spermatozoa.
Sign Up to like & getrecommendations! Published in 2017 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2017.08.016
Abstract: The mammalian epididymis provides an appropriate environment for sperm maturation. During the epididymal transit, spermatozoa undergo biochemical and morphological changes that lead to the acquisition of the fertilizing capacity. In this study we analysed the… read more here.
Keywords: bull; fucosidase; spermatozoa; epididymal fucosidase ... See more keywords
A novel broad specificity fucosidase capable of core α1-6 fucose release from N-glycans labeled with urea-linked fluorescent dyes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27797-0
Abstract: Exoglycosidases are often used for detailed characterization of glycan structures. Bovine kidney α-fucosidase is commonly used to determine the presence of core α1-6 fucose on N-glycans, an important modification of glycoproteins. Recently, several studies have… read more here.
Keywords: fucosidase; glycans labeled; core fucose; fucose glycans ... See more keywords
Dual role of fucosidase in cancers and its clinical potential
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.75840
Abstract: Glycosidases and glycosyltransferases greatly impact malignant phenotype of tumors though genetics and epigenetics mechanisms. As the member of glycoside hydrolase (GH) families 29A, α-L-fucosidases (AFUs) are involved in the hydrolysis of terminal L-fucose residues linked… read more here.
Keywords: clinical potential; fucosidase cancers; role fucosidase; cancers clinical ... See more keywords