The role of FUT8‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24345
Abstract: Fucosylation, especially core fucosylation of N‐glycans catalyzed by α1‐6 fucosyltransferase (fucosyltransferase 8 or FUT8), plays an important role in regulating the peripheral immune system and inflammation. However, its role in microglial activation is poorly understood.… read more here.
Keywords: fucosylation; activation; role; core fucosylation ... See more keywords
Fucosylation genes as circulating biomarkers for lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2735-0
Abstract: PurposeFucosyltransferases (FUTs) catalyze fucosylation, which plays a central role in biological processes. Aberrant fucosylation is associated with malignant transformation. Here we investigated whether transcriptional levels of genes coding the FUTs in plasma could provide cell-free… read more here.
Keywords: circulating biomarkers; fucosylation; biomarkers lung; lung cancer ... See more keywords
A Low FUT(2) Diet For a High-Fat World: Connecting Intestinal Fucosylation With Western Diet–Driven Liver Disease
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.05.005
Abstract: ith the rise of the high-fat and sugar “Western Wdiet,” many countries face a growing epidemic of obesity and its related comorbidities. Outside of extreme dietary changes in society, identifying and targeting genetic pathways that… read more here.
Keywords: fut2 mutants; fucosylation; western diet; gastroenterology ... See more keywords
Protein O-fucosylation: structure and function.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2018.12.005
Abstract: Fucose is a common terminal modification on protein and lipid glycans. Fucose can also be directly linked to protein via an O-linkage to Serine or Threonine residues located within consensus sequences contained in Epidermal Growth… read more here.
Keywords: protein fucosylation; egf repeats; fucosylation; function ... See more keywords
Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa
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DOI: 10.1038/s41598-017-13845-8
Abstract: Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fucosylation of IgG1-Fc N-glycans negatively… read more here.
Keywords: igg1; core fucosylation; fucosylation; riiia ... See more keywords
Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17193-5
Abstract: Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation of several signaling pathways, mainly the TGF-β and PDGF pathways, initiates the pericyte-myofibroblast transition during RIF. Key receptors… read more here.
Keywords: transition; core fucosylation; fucosylation; pericyte ... See more keywords
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-019-57393-9
Abstract: Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays and clinical trials. Structural variations… read more here.
Keywords: cell lines; fucosylation; efficacy; glycosylation ... See more keywords
Quantitative analysis of fucosylated glycoproteins by immobilized lectin-affinity fluorescent labeling
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00072a
Abstract: Human biofluids are often used to discover disease-specific glycosylation, since abnormal changes in protein glycosylation can discern physiopathological states. Highly glycosylated proteins in biofluids make it possible to identify disease signatures. Glycoproteomic studies on saliva… read more here.
Keywords: analysis fucosylated; fucosylation; fucosylated glycoproteins; lectin affinity ... See more keywords
Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2039485
Abstract: ABSTRACT Eriodictyol is a natural flavonoid with many pharmacological effects, such as anti-oxidation, anti-inflammation, anti-tumor, and neuroprotection. Besides, it has been reported that flavonoids play an important role in protein glycosylation. The fucosylation structure is… read more here.
Keywords: expression restrain; fucosylation; eriodictyol suppresses; tsta3 expression ... See more keywords
Role of poFUT1 and O-fucosylation in placental angiogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad011
Abstract: Abstract Trophoblast cells are critical to placental angiogenesis in the first trimester of pregnancy. Dysfunction of trophoblast leads to defective vascular remodeling and impaired angiogenesis, which is believed as the major cause of placental insufficiency… read more here.
Keywords: pofut1; fucosylation; angiogenesis; trophoblast cells ... See more keywords
Cell-wall fucosylation in Arabidopsis influences control of leaf water loss and alters stomatal development and mechanical properties.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of experimental botany"
DOI: 10.1093/jxb/erad039
Abstract: The Arabidopsis sensitive-to-freezing8 (sfr8) mutant exhibits reduced cell-wall (CW) fucose levels and compromised freezing tolerance. To examine whether CW fucosylation affects the response to desiccation also, we tested the effect of leaf excision in sfr8… read more here.
Keywords: leaf water; water loss; fucosylation; sfr8 ... See more keywords