Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506576
Abstract: The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a colitis treatment modality by promoting gut… read more here.
Keywords: gut homeostasis; fucosylation; colitis; akkermansia muciniphila ... See more keywords
Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells
Sign Up to like & getrecommendations! Published in 2024 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202300234
Abstract: Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of for example… read more here.
Keywords: fucosylation; differentially fucosylated; artificial mirnas; cho production ... See more keywords
The role of FUT8‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia
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DOI: 10.1002/glia.24345
Abstract: Fucosylation, especially core fucosylation of N‐glycans catalyzed by α1‐6 fucosyltransferase (fucosyltransferase 8 or FUT8), plays an important role in regulating the peripheral immune system and inflammation. However, its role in microglial activation is poorly understood.… read more here.
Keywords: fucosylation; activation; role; core fucosylation ... See more keywords
Fucosylation genes as circulating biomarkers for lung cancer
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DOI: 10.1007/s00432-018-2735-0
Abstract: PurposeFucosyltransferases (FUTs) catalyze fucosylation, which plays a central role in biological processes. Aberrant fucosylation is associated with malignant transformation. Here we investigated whether transcriptional levels of genes coding the FUTs in plasma could provide cell-free… read more here.
Keywords: circulating biomarkers; fucosylation; biomarkers lung; lung cancer ... See more keywords
A Low FUT(2) Diet For a High-Fat World: Connecting Intestinal Fucosylation With Western Diet–Driven Liver Disease
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.05.005
Abstract: ith the rise of the high-fat and sugar “Western Wdiet,” many countries face a growing epidemic of obesity and its related comorbidities. Outside of extreme dietary changes in society, identifying and targeting genetic pathways that… read more here.
Keywords: fut2 mutants; fucosylation; western diet; gastroenterology ... See more keywords
Protein O-fucosylation: structure and function.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2018.12.005
Abstract: Fucose is a common terminal modification on protein and lipid glycans. Fucose can also be directly linked to protein via an O-linkage to Serine or Threonine residues located within consensus sequences contained in Epidermal Growth… read more here.
Keywords: protein fucosylation; egf repeats; fucosylation; function ... See more keywords
Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c06435
Abstract: A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved. The objective of this study was to investigate the regulatory effect of KFP on the… read more here.
Keywords: microbiota dependent; gut microbiota; colon; metabolism ... See more keywords
Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa
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DOI: 10.1038/s41598-017-13845-8
Abstract: Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fucosylation of IgG1-Fc N-glycans negatively… read more here.
Keywords: igg1; core fucosylation; fucosylation; riiia ... See more keywords
Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
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DOI: 10.1038/s41598-017-17193-5
Abstract: Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation of several signaling pathways, mainly the TGF-β and PDGF pathways, initiates the pericyte-myofibroblast transition during RIF. Key receptors… read more here.
Keywords: transition; core fucosylation; fucosylation; pericyte ... See more keywords
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-019-57393-9
Abstract: Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays and clinical trials. Structural variations… read more here.
Keywords: cell lines; fucosylation; efficacy; glycosylation ... See more keywords
Quantitative analysis of fucosylated glycoproteins by immobilized lectin-affinity fluorescent labeling
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00072a
Abstract: Human biofluids are often used to discover disease-specific glycosylation, since abnormal changes in protein glycosylation can discern physiopathological states. Highly glycosylated proteins in biofluids make it possible to identify disease signatures. Glycoproteomic studies on saliva… read more here.
Keywords: analysis fucosylated; fucosylation; fucosylated glycoproteins; lectin affinity ... See more keywords