Comparison of enzymatic-and bisulfite conversion to map the plasma cell-free methylome in cancer
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DOI: 10.1093/annonc/mdz238.045
Abstract: Abstract Background Aberrant methylation is pervasive in cancer and a promising source of diagnostic and predictive biomarkers. Bisulfite conversion, the current standard for detecting methylated cytosines, requires higher DNA input requirements due to destruction of… read more here.
Keywords: bio inc; lexent; full part; lexent bio ... See more keywords
Evaluation of microsatellite instability testing through cell-free DNA sequencing
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DOI: 10.1093/annonc/mdz239.026
Abstract: Abstract Background Microsatellite instability (MSI) status has been approved by FDA to select for patients with metastatic tumors for cancer immunotherapy treatments. Additionally, MSI status is used in assessment of prognosis and treatment choices in… read more here.
Keywords: time employment; full part; time; illumina ... See more keywords
Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma
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DOI: 10.1093/annonc/mdz239.042
Abstract: Abstract Background Malignant mesothelioma is an aggressive cancer with poor prognosis and few effective therapies. Due to its derivation from the mesothelium of the lung, immune cells in the tumor microenvironment (TME) may behave differently… read more here.
Keywords: time employment; full part; advisory consultancy; part time ... See more keywords
Lurbinectedin (LUR) in combination with irinotecan (IRI) in patients (pts) with advanced solid tumours
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DOI: 10.1093/annonc/mdz244.033
Abstract: Abstract Background LUR is a new agent that exerts antitumor activity through inhibition of trans-activated transcription and modulation of tumor microenvironment. Preclinical synergism/additivity in combination with IRI has been reported, thus prompting the conduct of… read more here.
Keywords: time employment; full part; iri; pharmamar ... See more keywords
SPICE, a phase I study of enadenotucirev in combination with nivolumab in tumours of epithelial origin: Analysis of the metastatic colorectal cancer patients in the dose escalation phase
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DOI: 10.1093/annonc/mdz246.089
Abstract: Abstract Background Enadenotucirev (EnAd) is a tumor-selective chimeric Ad11/Ad3 group B oncolytic adenovirus. Following IV dosing of EnAd, viral delivery has been shown in various carcinomas together with CD8+ T-cells. These data provide a rationale… read more here.
Keywords: phase; psioxus; time employment; full part ... See more keywords
Evaluation of niraparib 200 mg/d as maintenance therapy in recurrent ovarian cancer and associated thrombocytopenia in a real-world US setting
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DOI: 10.1093/annonc/mdz250.013
Abstract: Abstract Background Niraparib, a poly(ADP-ribose) polymerase inhibitor approved in 2017 by the US FDA (300 mg/d), has proven to be efficacious as maintenance therapy in patients (pts) with recurrent epithelial ovarian, fallopian tube, or primary peritoneal… read more here.
Keywords: full part; time; part time; oncology ... See more keywords
Mutational landscapes and tumour mutational burden expression in endometrial cancer
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DOI: 10.1093/annonc/mdz250.048
Abstract: Abstract Background Endometrial cancer (EC) is one of the most common gynaecological tumours. Tumour mutational burden (TMB) has emerged as a promising predictor to evaluate efficacy to immunotherapy in several kinds of solid tumours. However,… read more here.
Keywords: part time; full part; time employment; employment origimed ... See more keywords
THOR-707, a novel not-alpha IL-2, promotes all key immune system anti-tumoral actions of IL-2 without eliciting vascular leak syndrome (VLS)
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DOI: 10.1093/annonc/mdz253.051
Abstract: Abstract Background THOR-707 is a reprogrammed, site-directed, single pegylated, recombinant human IL-2 (rIL-2) variant that lacks binding affinity for the α chain of the IL-2 receptor. Because THOR-707 has near-native binding affinity for the βγ… read more here.
Keywords: time; time employment; synthorx inc; full part ... See more keywords
Lerociclib (G1T38), an oral CDK4/6 inhibitor, dosed continuously in combination with osimertinib for EGFRmut non-small cell lung cancer: Initial phase Ib results
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DOI: 10.1093/annonc/mdz260.059
Abstract: Abstract Background Lerociclib (lero) is a potent, selective oral CDK4/6 inhibitor (CDK4/6i). Preclinical and early clinical data have demonstrated that lero is differentiated based on its favorable safety/tolerability profile and ability to be dosed continuously… read more here.
Keywords: time employment; full part; honoraria self; part time ... See more keywords
Adherence to ESMO 2014 guidelines on bone-targeting agent (BTA) initiation for breast and prostate cancer patients: Real-world insights from practicing European physicians
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DOI: 10.1093/annonc/mdz265.038
Abstract: Abstract Background Despite existing clinical guidelines on bone health in patients with cancer (ESMO 2014), the use of recommended BTA is sub-optimal for many patients. It is unclear if physicians’ decisions are aligned with ESMO’s… read more here.
Keywords: time employment; part time; full part; bone ... See more keywords
Epidemiology of synovial sarcoma in EU28 countries
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DOI: 10.1093/annonc/mdz283.061
Abstract: Abstract Background Synovial sarcoma (SS) is a rare and aggressive soft tissue sarcoma which primarily affects the extremities of arms and legs. It also occurs in head and neck, trunk, lungs and pleura. Brennan et… read more here.
Keywords: eu28 countries; full part; epidemiology; part time ... See more keywords