Generation and characterization of a potent fully human monoclonal antibody against the interleukin‐23 receptor
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.036
Abstract: ABSTRACT Interleukin (IL)‐12 and IL‐23 share a common subunit (p40) and function in T‐helper (Th) 1 and Th17 immunity, respectively. Anti‐IL‐12/23p40 and specific anti‐IL‐23 antibodies are currently in clinical use for psoriasis and undergoing trials… read more here.
Keywords: human monoclonal; antibody; fully human; generation characterization ... See more keywords
Safety, tolerability and efficacy of repeated intravenous infusions of KHK4083, a fully human anti-OX40 monoclonal antibody, in Japanese patients with moderate to severe atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.06.005
Abstract: BACKGROUND KHK4083, a fully human anti-OX40 monoclonal antibody, is a potential novel therapeutic option for moderate to severe atopic dermatitis (AD), targeting the immunopathogenic pathways. OBJECTIVE Assess the safety and tolerability of repeated doses of… read more here.
Keywords: safety; khk4083 fully; fully human; patients moderate ... See more keywords
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102386
Abstract: Neurogenin 2 encodes a neural-specific transcription factor (NGN2) able to drive neuronal fate on somatic and stem cells. NGN2 is expressed in neural progenitors within the developing central and peripheral nervous systems. Overexpression of NGN2… read more here.
Keywords: neurons cultured; development fully; fully human; stem cells ... See more keywords
Preclinical Study of a Fully Human Anti-PD-L1 Antibody as a Theranostic Agent for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00371
Abstract: Recently, inhibiting the PD-1/PD-L1 checkpoint pathway utilizing anti-PD-1 or anti-PD-L1 antibodies has achieved great clinical success in cancer treatment. However, anti-PD-1 immunotherapy cannot be applied to all cancer patients, no more than 25% showed a… read more here.
Keywords: anti antibody; immunotherapy; fully human; expression ... See more keywords
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06934-3
Abstract: The current expansion of autologous human keratinocytes to resurface severe wound defects still relies on murine feeder layer and calf serum in the cell culture system. Through our characterization efforts of the human skin basement… read more here.
Keywords: system; fully human; human epidermal; culture ... See more keywords
726 SRF114 is a fully human, CCR8 selective IgG1 antibody that induces destruction of tumor Tregs through ADCC
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0726
Abstract: Background T regulatory cells (Tregs) are potent suppressors of immune activation in the periphery and tumor microenvironment (TME). Tumor-infiltrating Tregs have also been associated with resistance to cancer therapies. Loss of peripheral Tregs can lead… read more here.
Keywords: ccr8; antibody; fully human; cell ... See more keywords
Abstract LB-002: A fully human antibody binds Tn and sTn carbohydrate antigens specifically on serine residues, without need for polypeptide interaction
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-lb-002
Abstract: Background: Thompsen-nouvelle (Tn) antigen is an O-linked glycan that is associated with a broad array of tumors. Tn is a single alpha-linked GalNAc added to Ser or Thr as the first step of a major… read more here.
Keywords: human antibody; thr; antibody; fully human ... See more keywords
Abstract 561: Development of competing and non-competing fully human internalizing anti-Her2 monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-561
Abstract: The human epidermal growth factor receptor (HER) family of receptors has been implicated in several human cancers. Among them, HER2 is overexpressed in several cancers with or without gene amplification with prognostic and predictive implications.… read more here.
Keywords: fully human; her2 monoclonal; internalizing anti; human internalizing ... See more keywords
(Re)Thinking children as fully (in)human and literacies as otherwise through (re)etymologizing intervene and inequality
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Early Childhood Literacy"
DOI: 10.1177/1468798420904774
Abstract: In response to the guest editors’ call to attend to literacy and language as bodily practices and to (re)think social inequality in young children’s literacies, we read a couple of publications by Rosi Braidotti, Maggie… read more here.
Keywords: intervene inequality; children fully; fully human; human literacies ... See more keywords
Perioperative MVT-5873, a fully human monoclonal antibody against a CA 19-9 epitope, for operable CA 19-9 producing pancreatic cancers, cholangiocarcinomas, and metastatic colorectal cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps4655
Abstract: TPS4655Background: Operable hepatopancreatobiliary (HPB) cancers continue to pose significant challenges. Radical resections are rarely curative, and chemotherapy is able to reduce tumor recurrence... read more here.
Keywords: 5873 fully; human monoclonal; fully human; mvt 5873 ... See more keywords
A fully human neutralizing monoclonal antibody targeting a highly conserved epitope of the human cytomegalovirus glycoprotein B
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285672
Abstract: Human cytomegalovirus causes severe diseases in children (by congenital infection) and immunocompromised patients. Treatment with antiviral agents, such as ganciclovir, is limited by their toxicity. In this study, we investigated the effectiveness of a fully… read more here.
Keywords: fully human; glycoprotein; cytomegalovirus; human cytomegalovirus ... See more keywords