Enantioselective Assembly of Fully Substituted α‐Amino Allenoates Through a Mannich Addition and Stepwise [3,3]‐σ Rearrangement Sequence
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202409334
Abstract: Chiral fully‐substituted allenes are synthetically significant and pivotal building blocks that can engage in diverse transformations toward a variety of bioactive molecules. The enantioselective assembly of these skeletons using readily available reactants offers significant advantages… read more here.
Keywords: stepwise rearrangement; rearrangement sequence; addition stepwise; addition ... See more keywords
Copper(I)‐Catalyzed CuAIAC/Allylation Cascade: Modular Synthesis of Fully Substituted Allyl N,N′ ‐Bicyclic Pyrazolidinones
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.70272
Abstract: A copper(I)‐catalyzed CuAIAC/allylation cascade reaction exploiting alkynes, azomethine imines, and allyl bromides has been developed for providing rapid access to fully substituted allyl N,N ′‐bicyclic pyrazolidinones, involving the formation of C(sp 2 )–C(sp 3 )… read more here.
Keywords: catalyzed cuaiac; cuaiac allylation; substituted allyl; fully substituted ... See more keywords
Influence of fatty chain length and starch composition on structure and properties of fully substituted fatty acid starch esters.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.02.013
Abstract: A series of almost fully substituted Fatty Acid Starch Esters (FASEs) has been obtained in a homogeneous LiCl/DMAc medium by grafting octanoyl (C8), lauroyl (C12) and palmitoyl (C16) chlorides onto 3 starch species: Amylo-Maize, Potato… read more here.
Keywords: chain; fully substituted; chain length; fatty acid ... See more keywords
Cyclic acyl amidines as unexpected C4-donors for fully substituted pyridine ring formation in the base mediated reaction with malononitrile
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.06.038
Abstract: Abstract A new one-step, pseudo four-component approach for the synthesis of fully substituted pyridines via ring-opening of the cyclic acyl amidine of 3-amino-1 H -isoindol-1-one and its aza-analogues during the reaction with malononitrile in the… read more here.
Keywords: pyridine ring; cyclic acyl; reaction; reaction malononitrile ... See more keywords
Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02578
Abstract: In the presence of a catalytic amount of Pd(OAc)2 and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and… read more here.
Keywords: fully substituted; multicomponent synthesis; synthesis fully; palladium catalyzed ... See more keywords
Regioselective Synthesis of Fully Substituted Fused Pyrroles through an Oxidant-Free Multicomponent Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03889
Abstract: The synthesis of fully substituted fused pyrroles through a multicomponent reaction between a thioamide, an aldehyde, and ammonium acetate is described. This process improves on a route commonly employed in the patent literature by avoiding… read more here.
Keywords: fused pyrroles; multicomponent reaction; substituted fused; reaction ... See more keywords
Rhodium(I)-Catalyzed Cascade Annulation of 1,n-Diynyl Nitrones to 3,4-Fused Fully Substituted Furans.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02287
Abstract: A method for the assembly of fully substituted furans containing a 3,4-fused 5-8-membered carbocycle, heterocycle, or spirocycle from rhodium(I)-catalyzed and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)-assisted cascade annulation of 1,n-diynyl nitrones has been developed. read more here.
Keywords: annulation diynyl; substituted furans; rhodium catalyzed; cascade annulation ... See more keywords
Stereoselective Alkyne-Alkene [2 + 2] Cycloaddition Enabled by Anion Relay Chemistry for Fully C-Substituted Cyclobutene Synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.4c04255
Abstract: Cyclobutenes serve as valuable scaffolds in pharmaceutical development, but synthesizing structurally diverse fully C-substituted cyclobutenes remains challenging. Here we report a stereoselective [2 + 2] cycloaddition between alkynyl 1,3-dithianes and cinnamate esters using a catalytic… read more here.
Keywords: chemistry; anion relay; relay chemistry; fully substituted ... See more keywords
Construction of N-Heterocyclic Systems Containing a Fully Substituted Allylic Carbon by Palladium/Phosphine Catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03127
Abstract: The unique cyclization of benzamide derivatives that contain an alkyne by a Pd(0)/dialkyl(biaryl)phosphine catalytic system is reported. The reaction efficiently provides a variety of six-membered N-heterocyclic compounds that contain a fully substituted carbon center without… read more here.
Keywords: fully substituted; carbon; phosphine; systems containing ... See more keywords
Copper-Catalyzed Three-Component Cascade Michael Addition/Heck-Type Alkylation/Annulation: Accessing Fully Substituted 1,3-Dihydro-2H-pyrrol-2-ones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03189
Abstract: We report a highly efficient copper-catalyzed three-component reaction of alkylamines, acetylenedicarboxylates, and α-bromocarbonyls for the assembly of fully substituted 1,3-dihydro-2H-pyrrol-2-ones. A variety of alkylamines and ammonium salt are functionalized with acetylenedicarboxylates and α-bromocarbonyls. N-aryl enaminoesters… read more here.
Keywords: fully substituted; substituted dihydro; dihydro pyrrol; catalyzed three ... See more keywords
DBU-mediated [4 + 2] annulations of donor–acceptor cyclopropanes with 3-aryl-2-cyanoacrylates for the synthesis of fully substituted anilines
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra07230a
Abstract: A facile synthesis of fully substituted anilines by the DBU-mediated [4 + 2] annulation of donor–acceptor 1,1-dicyano-cyclopropanes with 3-aryl-2-cyanoacrylate has been developed. This reaction involves a highly efficient multiple domino sequence consisting of ring opening… read more here.
Keywords: substituted anilines; fully substituted; synthesis fully; donor acceptor ... See more keywords