Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine Models
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.01.001
Abstract: Background & Aims Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In this study, we aimed… read more here.
Keywords: liver failure; treatment; inhibition; acute liver ... See more keywords
Thirty‐two years' experience of treating fulminant hepatitis in a Japanese single center
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology Research"
DOI: 10.1111/hepr.13873
Abstract: The prognosis of patients with acute liver failure has improved dramatically in the past three decades due to advances in medical critical care and use of liver transplantation (LT) in Western countries, where the etiology… read more here.
Keywords: thirty two; experience treating; two years; hepatitis ... See more keywords
Protective effects of glutamine on lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221126562
Abstract: Fulminant hepatitis remains a critical health problem owing to its high mortality rate and the lack of effective therapies. An increasing number of studies have shown that glutamine supplementation provides protective benefits in inflammation-related disorders,… read more here.
Keywords: glutamine lipopolysaccharide; induced fulminant; lps gal; hepatitis ... See more keywords
Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice
Sign Up to like & getrecommendations! Published in 2018 at "BMC Immunology"
DOI: 10.1186/s12865-018-0256-x
Abstract: BackgroundPotassium channel tetramerisation domain containing 9 (KCTD9), a member of KCTD family with a DNA-like pentapeptide repeat domain, was found to be increased particularly in NK cells of patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF)… read more here.
Keywords: liver failure; cell activation; viral fulminant; cell ... See more keywords
The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice
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DOI: 10.1538/expanim.20-0014
Abstract: The metabolic sensor sirtuin 1 (SIRT1) also functions as a checkpoint in inflammation, and SRT1720 is a highly active and selective SIRT1 activator shown to alleviate inflammatory injury in several recent experimental studies. In the… read more here.
Keywords: fulminant hepatitis; activator srt1720; induced fulminant; srt1720 ... See more keywords
Therapeutics for fulminant hepatitis caused by enteroviruses in neonates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1014823
Abstract: Neonatal infection with nonpolio enteroviruses (EVs) causes nonspecific febrile illnesses and even life-threatening multiorgan failure. Hepatitis, which often results in hepatic necrosis followed by disseminated intravascular coagulopathy, is one of the most severe and frequent… read more here.
Keywords: neonatal infection; therapeutics fulminant; infection; hepatitis caused ... See more keywords
Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i4.479
Abstract: BACKGROUND Heterogeneous macrophages play an important role in multiple liver diseases, including viral fulminant hepatitis (VFH). Fibrinogen-like protein 2 (FGL2) is expressed on macrophages and regulates VFH pathogenesis; however, the underlying mechanism remains unclear. AIM… read more here.
Keywords: liver damage; fibrinogen like; fulminant hepatitis; fgl2 ... See more keywords
Galectin-9 ameliorates fulminant liver injury
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DOI: 10.3892/mmr.2017.6606
Abstract: Fulminant hepatitis is a severe liver disease resulting in hepatocyte necrosis. Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has been evaluated as a potential therapeutic agent for various diseases that regulate the host immune system.… read more here.
Keywords: galectin; hepatitis; effects gal; liver injury ... See more keywords
Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells
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DOI: 10.7150/thno.65916
Abstract: Fulminant hepatitis (FH) is a life-threatening disease with partially understood pathogenesis. It has been demonstrated that myeloid-derived suppressor cells (MDSCs) are recruited into the liver during this process, and their augmented accumulation by various strategies… read more here.
Keywords: myeloid derived; fulminant hepatitis; rack1; hepatic rack1 ... See more keywords