A conserved motif liganding the [4Fe–4S] cluster in [4Fe–4S] fumarases prevents irreversible inactivation of the enzyme during hydrogen peroxide stress
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101296
Abstract: Organisms have evolved two different classes of the ubiquitous enzyme fumarase: the [4Fe–4S] cluster-containing class I enzymes are oxidant-sensitive, whereas the class II enzymes are iron-free and therefore oxidant-resistant. When hydrogen peroxide (H2O2) attacks the… read more here.
Keywords: 4fe fumarases; hydrogen peroxide; fumarase; 4fe cluster ... See more keywords
Biochemical characterisation of fumarase C from a unicellular cyanobacterium demonstrating its substrate affinity, altered by an amino acid substitution
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DOI: 10.1038/s41598-019-47025-7
Abstract: The tricarboxylic acid cycle produces NADH for oxidative phosphorylation and fumarase [EC 4.2.1.2] is a critical enzyme in this cycle, catalysing the reversible conversion of fumarate and l-malate. Fumarase is applied to industrial l-malate production… read more here.
Keywords: amino acid; malate; substrate affinity; substitution ... See more keywords
Fumarase: From the TCA Cycle to DNA Damage Response and Tumor Suppression
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DOI: 10.3389/fmolb.2018.00068
Abstract: Fumarase is an enzyme of the tricarboxylic acid (TCA) cycle in mitochondria, but in recent years, it has emerged as a participant in the response to DNA double strand breaks (DSBs) in the nucleus. In… read more here.
Keywords: dna damage; damage response; response; fumarate ... See more keywords