Immunological predictors of dimethyl fumarate-induced lymphopenia.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of neurology"
DOI: 10.1002/ana.26328
Abstract: OBJECTIVE Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. METHODS This prospective observational… read more here.
Keywords: dimethyl fumarate; induced lymphopenia; fumarate induced; predictors dimethyl ... See more keywords
Assessment of the sensitivity of 2 H MR spectroscopy measurements of [2,3-2 H2 ]fumarate metabolism for detecting tumor cell death.
Sign Up to like & getrecommendations! Published in 2023 at "NMR in biomedicine"
DOI: 10.1002/nbm.4965
Abstract: Imaging the metabolism of [2,3-2 H2 ]fumarate to produce malate can be used to detect tumor cell death post-treatment. Here we assess the sensitivity of the technique for detecting cell death by lowering the concentration… read more here.
Keywords: cell death; spectroscopy; fumarate; tumor ... See more keywords
Reduction of Fumarate to Succinate Mediated by Fusobacterium varium
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2817-0
Abstract: Accumulation of succinate as a fermentation product of Fusobacterium varium was enhanced when the anaerobic bacterium was grown on complex peptone medium supplemented with fumarate. Residual substrates and fermentation products were determined by proton NMR… read more here.
Keywords: fumarate; succinate; fumarate succinate; fusobacterium varium ... See more keywords
Dimethyl Fumarate: A Review in Relapsing-Remitting MS
Sign Up to like & getrecommendations! Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01229-3
Abstract: Dimethyl fumarate (Tecfidera®) is approved for the treatment of relapsing forms of multiple sclerosis (MS). Based on evidence from the clinical trial and real-world settings, dimethyl fumarate is an effective treatment in this patient population,… read more here.
Keywords: relapsing remitting; fumarate review; fumarate; review relapsing ... See more keywords
Investigation into the antimicrobial activity of fumarate against Listeria monocytogenes and its mode of action under acidic conditions.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of food microbiology"
DOI: 10.1016/j.ijfoodmicro.2020.108614
Abstract: Organic acids such as fumarate are commonly used as antimicrobials in foods. Apart from the classical mechanism of intracellular dissociation, weak acids are active through important additional mechanisms which are not well-defined. Fumarate, based on… read more here.
Keywords: system; antimicrobial activity; fumarate; gad system ... See more keywords
Efficacy of in situ well-based denitrification bio-barrier (WDB) remediating high nitrate flux in groundwater near a stock-raising complex.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2019.110004
Abstract: This study assessed the feasibility of an in situ well-based denitrification bio-barrier (WDB) for managing groundwater contaminated with high-strength nitrate. To evaluate the efficacy of WDB using fumarate as a carbon source and/or electron donor,… read more here.
Keywords: well based; based denitrification; fumarate; nitrate ... See more keywords
A mechanism of modulating the direction of flagellar rotation in bacteria by fumarate and fumarate reductase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.08.001
Abstract: Fumarate, an electron acceptor in anaerobic respiration of Escherichia coli, has an additional function of assisting the flagellar motor to shift from counterclockwise to clockwise rotation, with a consequent modulation of the bacterial swimming behavior.… read more here.
Keywords: clockwise rotation; mechanism; fumarate; rotation ... See more keywords
Bioanalysis of monomethyl fumarate in human plasma by a sensitive and rapid LC–MS/MS method and its pharmacokinetic application
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.08.015
Abstract: HIGHLIGHTSFirst LC–MS/MS report for determination of monomethyl fumarate in human plasma.Use of stable labeled isotope as IS for any variability during extraction and LC–MS/MS analysis.The method employs only 100 &mgr;L of plasma for processing using… read more here.
Keywords: plasma; monomethyl fumarate; human plasma; fumarate ... See more keywords
Dissecting Reaction Mechanisms and Catalytic Contributions in Flavoprotein Fumarate Reductases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00292
Abstract: The interconversion between fumarate and succinate is fundamental to the energy metabolism of nearly all organisms. This redox reaction is catalyzed by a large family of enzymes, fumarate reductases and succinate dehydrogenases, using hydride and… read more here.
Keywords: fumarate reductases; reaction; reaction mechanisms; active site ... See more keywords
Dimethyl fumarate: targeting glycolysis to treat MS
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0045-3
Abstract: Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of… read more here.
Keywords: glycolysis; gapdh; fumarate; dmf ... See more keywords
Hyperpolarized [1,4-13C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66265-6
Abstract: Today, there is a general lack of prognostic biomarkers for development of renal disease and in particular diabetic nephropathy. Increased glycolytic activity, lactate accumulation and altered mitochondrial oxygen utilization are hallmarks of diabetic kidney disease.… read more here.
Keywords: death; cell death; fumarate; diabetic nephropathy ... See more keywords