A Review of FUN14 Domain‐Containing 1 Involvement in Mitochondrial Biological Processes and Mechanisms Across Various Systems
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70125
Abstract: FUN14 domain‐containing 1 (FUNDC1), an outer mitochondrial membrane protein, has emerged as a critical regulator of mitochondrial quality control and cellular homeostasis. Initially identified as a mitophagy receptor, FUNDC1 orchestrates hypoxia‐induced mitophagy through phosphorylation‐dependent interactions… read more here.
Keywords: involvement mitochondrial; containing involvement; domain containing; fun14 domain ... See more keywords
FUN14 domain-containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106964
Abstract: Mitochondria play a critical role in triggering immune response. Although recent evidence indicates that autophagy/mitophagy can suppress inflammation via regulation of mitochondrial homeostasis, limited information is available regarding physiological regulation of mitochondria-controlled inflammation. In this… read more here.
Keywords: mediated mitophagy; domain containing; production; fun14 domain ... See more keywords
FUN14 Domain Containing 1 (FUNDC1): A Promising Mitophagy Receptor Regulating Mitochondrial Homeostasis in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.887045
Abstract: Mitochondria, the intracellular organelles for cellular aerobic respiration and energy production, play an important role in the regulation of cell metabolism and cell fate. Mitophagy, a selective form of autophagy, maintains dynamic homeostasis of cells… read more here.
Keywords: cardiovascular diseases; mitophagy; receptor; homeostasis ... See more keywords