A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101870
Abstract: Summary Among laboratory mouse strains many genes are differentially expressed in the same cell population. As consequence, gene targeting in 129-derived embryonic stem cells (ESCs) and backcrossing the modified mice onto the C57BL/6 background can… read more here.
Keywords: passenger mutation; function cells; mice; p2rx7 passenger ... See more keywords
Assessment of antitumor function of NK cells expanded with exosomes from K562.mb21 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.132
Abstract: 132Background: NK cells can kill malignant cells to provide innate immunity against tumors. Due to their low abundance in blood, a focus is to expand NK cells ex vivo having enhanced anti-tumor cyt... read more here.
Keywords: assessment antitumor; exosomes k562; expanded exosomes; function cells ... See more keywords
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00580
Abstract: The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other… read more here.
Keywords: regulation development; cells zbtb; function cells; function ... See more keywords
Revisiting the Antigen-Presenting Function of β Cells in T1D Pathogenesis
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DOI: 10.3389/fimmu.2021.690783
Abstract: Type 1 diabetes (T1D) is characterized by the unresolved autoimmune inflammation and islet β cell destruction. The islet resident antigen-presenting cells (APCs) including dendritic cells and macrophages uptake and process the β cell-derived antigens to… read more here.
Keywords: presenting function; function cells; antigen; antigen presenting ... See more keywords
Mutation of the Polyproline Sequence in CD3ε Evidences TCR Signaling Requirements for Differentiation and Function of Pro-Inflammatory Tγδ17 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.799919
Abstract: Tγδ17 cells have emerged as a key population in the development of inflammatory and autoimmune conditions such as psoriasis. Thus, the therapeutic intervention of Tγδ17 cells can exert protective effects in this type of pathologies.… read more here.
Keywords: function; sequence; tcr signaling; function cells ... See more keywords
Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review
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DOI: 10.3390/antiox10020293
Abstract: Lipotoxicity is a major contributor to type 2 diabetes mainly promoting mitochondrial dysfunction. Lipotoxic stress is mediated by elevated levels of free fatty acids through various mechanisms and pathways. Impaired peroxisome proliferator-activated receptor (PPAR) signaling,… read more here.
Keywords: lipotoxic impairment; fatty acids; function cells; cellular senescence ... See more keywords
Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032023
Abstract: Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased diabetes incidence. We… read more here.
Keywords: unfolded protein; function; function cells; protein response ... See more keywords