Antagonist-perturbation mechanism for activation function-2 fixed motifs: active conformation and docking mode of retinoid X receptor antagonists
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DOI: 10.1007/s10822-017-0025-6
Abstract: HX531, which contains a dibenzodiazepine skeleton, is one of the first retinoid X receptor (RXR) antagonists. Functioning via RXR-PPARĪ³ heterodimer, this compound is receiving a lot of attention as a therapeutic drug candidate for diabetic… read more here.
Keywords: function fixed; docking mode; active conformation; retinoid receptor ... See more keywords