TIM-3 shuttled by MV3 cells-secreted exosomes inhibits CD4+ T cell immune function and induces macrophage M2 polarization to promote the growth and metastasis of melanoma cells
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DOI: 10.1016/j.tranon.2021.101334
Abstract: Highlights • MV3-Exo inhibits CD4+ t cell immune function and induces M2-polarized macrophages.• TIM-3 is upregulated in MV3 cells-secreted exosomes.• TIM-3 inhibits CD4+ t cell immune function and induces M2-polarized macrophages.• TIM-3 shuttled by MV3-Exo… read more here.
Keywords: function induces; immune function; cd4 cell; metastasis melanoma ... See more keywords