Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
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DOI: 10.1038/s41467-017-00862-4
Abstract: Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein–protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the… read more here.
Keywords: function macrocyclase; peptide; dual function; macrocyclization ... See more keywords