The Function and Mechanisms of Autophagy in Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4272-5_46
Abstract: Traumatic brain injury (TBI) is one of the most common causes of long-term disability and death worldwide. Autophagy is activated and autophagic flux is impaired following TBI. But the controversial roles and underlying mechanisms of… read more here.
Keywords: brain injury; traumatic brain; mechanisms autophagy; function mechanisms ... See more keywords
Flavonoids: structure-function and mechanisms of action and opportunities for drug development.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-020-00080-z
Abstract: Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and dietary consumption of these structurally diverse compounds is associated with multiple health benefits including increased lifespan, decreased cardiovascular problems and low rates of metabolic… read more here.
Keywords: flavonoids structure; mechanisms action; function mechanisms; drug ... See more keywords
A distant angiogenin variant causes amyotrophic lateral sclerosis through loss-of-function mechanisms: Insights from long-timescale atomistic simulations and conformational dynamics
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.104602
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a progressive and incurable neurodegenerative disorder characterized by the degeneration of motor neurons leading to severe muscle atrophy, respiratory failure and death within 3-5 years of disease onset. Missense mutations… read more here.
Keywords: function mechanisms; loss function; amyotrophic lateral; function ... See more keywords
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac110
Abstract: Abstract A bidirectional relationship exists between hypertension and psychiatric disorders, including unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis, schizophrenia, mania, and dementia/cognitive decline. Repurposing of antihypertensive drugs to treat mental disorders is… read more here.
Keywords: brain function; brain; function mechanisms; antihypertensive drugs ... See more keywords
Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16028
Abstract: Hypertrophic scars are complications of severe wound healing characterized by excessive fibrosis associated with aberrant function of fibroblasts. However, no available drugs can be utilized to effectively treat these scars. The transforming growth factor β… read more here.
Keywords: novel small; function mechanisms; function; scar ... See more keywords