Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant
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DOI: 10.1073/pnas.2414768121
Abstract: Significance Many diseases stem from imbalances between protein synthesis and degradation that arise from mutations and/or cellular stressors. The molecular mechanisms of such lapses in proteostasis often coincide with aberrant regulation of protein translation. Here,… read more here.
Keywords: function pharmacological; assembly function; ribosomal frameshifting; modulates assembly ... See more keywords