Vericiguat improves cardiac remodelling and function in rats with doxorubicin‐induced cardiomyopathy
Sign Up to like & getrecommendations! Published in 2025 at "ESC Heart Failure"
DOI: 10.1002/ehf2.15186
Abstract: Vericiguat, a soluble guanylate cyclase (sGC) stimulator, has been demonstrated effective in improving prognosis of patients with heart failure with reduced ejection fraction. However, there are limited data concerning the effect of vericiguat in patients… read more here.
Keywords: improves cardiac; function rats; vericiguat improves; vericiguat ... See more keywords
MOTS-c modulates pancreatic islet function in rats and pigs in vitro
Sign Up to like & getrecommendations! Published in 2025 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-025-02391-4
Abstract: MOTS-c is a promising regulator of metabolism and energy homeostasis. While its effects have been studied in cell lines, our team aimed to investigate its influence on more complex structures—specifically, isolated pancreatic islets. We used… read more here.
Keywords: modulates pancreatic; function rats; mots modulates; islet function ... See more keywords
Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.201
Abstract: Bile acids (BAs) circulate between the liver and intestine, and regulate the homeostasis of glucose, lipid, and energy. Recent studies demonstrated an essential role of BAs in neurological diseases, suggesting an interaction between BAs and… read more here.
Keywords: intestine; function rats; impaired vagus; liver ... See more keywords
Bucindolol improves right ventricle function in rats with pulmonary arterial hypertension through the reversal of autonomic imbalance
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.12.028
Abstract: ABSTRACT Pulmonary arterial hypertension (PAH) is characterised by an elevation in afterload imposed on the right ventricle (RV), leading to hypertrophy and failure. The autonomic nervous system (ANS) plays a key role in the progression… read more here.
Keywords: function rats; arterial hypertension; pulmonary arterial; function ... See more keywords
Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.05.007
Abstract: &NA; Aerobic exercise (AE) benefits brain health and behavior. Serotonin (5‐HT) and brain‐derived neurotrophic factor (BDNF) are known to mediate and shape cognitive processes. Both systems share some actions: BDNF is involved in the maturation… read more here.
Keywords: function rats; cognitive function; function; aerobic exercise ... See more keywords
Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Andrologia"
DOI: 10.1111/and.12693
Abstract: Men with hyperlipidemia are more likely to have erectile dysfunction (ED) than those without hyperlipidemia, but the mechanisms are not fully understood. The aim of this study was to investigate the underlying mechanism of ED… read more here.
Keywords: erectile function; fibrosis; function rats; hyperlipidemia ... See more keywords
Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes
Sign Up to like & getrecommendations! Published in 2020 at "Cell Transplantation"
DOI: 10.1177/0963689720956956
Abstract: Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation of adipose-derived pericytes can improve… read more here.
Keywords: ischemic stroke; function rats; derived pericytes; neurological function ... See more keywords
Effects of a Three-Day vs. Six-Day Exposure to Normobaric Hypoxia on the Cardiopulmonary Function of Rats
Sign Up to like & getrecommendations! Published in 2025 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb47020125
Abstract: In rats, normobaric hypoxia significantly reduced left ventricular (LV) inotropic function while right ventricular (RV) function was not impaired. In parallel, the animals developed pulmonary edema and inflammation. In the present study, we investigated whether… read more here.
Keywords: function rats; function; hypoxia; exposure ... See more keywords