Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.4c01553
Abstract: Exenatide (Ex4), a GLP-1 incretin mimetic polypeptide, is an effective therapeutic agent against diabetes and obesity. We highlight the indirect role of Ex4’s structure-stabilizing Trp-cage (Tc) motif in governing GLP-1 receptor (GLP-1R) signal transduction. We… read more here.
Keywords: influence trp; stability; trp cage; function stability ... See more keywords
Uniting Form and Function, Stability and Reactivity in Open Framework Materials
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry Letters"
DOI: 10.1246/cl.200712
Abstract: Functions and performance metrics are much sought after by materials researchers and editors; not to be sidelined, however, are fundamental design works directed at general methodological breakthro... read more here.
Keywords: function stability; open framework; stability reactivity; form function ... See more keywords