Single-chromosome Gains Commonly Function as Tumor Suppressors.
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DOI: 10.1016/j.ccell.2016.12.004
Abstract: Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly… read more here.
Keywords: commonly function; single chromosome; chromosome gains; function tumor ... See more keywords