Evaluation of Arteriolar Smooth Muscle Cell Function in an Ex Vivo Microvascular Network Model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02272-4
Abstract: An emerging challenge in tissue engineering biomimetic models is recapitulating the physiological complexity associated with real tissues. Recently, our laboratory introduced the rat mesentery culture model as an ex vivo experimental platform for investigating the… read more here.
Keywords: model; function vivo; smooth muscle; microvascular network ... See more keywords
The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.40045
Abstract: DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1… read more here.
Keywords: ligand function; function vivo; function; dll1 dll4 ... See more keywords