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   Articles with "functional annotation" as a keyword



MiRLog and dbmiR: Prioritization and functional annotation tools to study human microRNA sequence variants

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recommendations! Published in 2022 at "Human Mutation"

DOI: 10.1002/humu.24399

Abstract: The recent identification of noncoding variants with pathogenic effects suggests that these variations could underlie a significant number of undiagnosed cases. Several computational methods have been developed to predict the functional impact of noncoding variants,… read more here.

Keywords: annotation tools; dbmir prioritization; mirlog dbmir; prioritization functional ... See more keywords
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Functional Annotation of MicroRNAs Using Existing Resources.

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recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1170-8_3

Abstract: MicroRNAs (miRNAs) are endogenous small noncoding RNAs that are involved in most biological signaling pathways, including the cell cycle, apoptosis, proliferation, immune response, metabolism as well as in biological processes including organ development and in… read more here.

Keywords: annotation micrornas; existing resources; functional annotation; biology ... See more keywords

Functional annotation of differentially expressed fetal cardiac microRNA targets: implication for microRNA-based cardiovascular therapeutics

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recommendations! Published in 2018 at "3 Biotech"

DOI: 10.1007/s13205-018-1520-8

Abstract: Gene expression pattern of a failing heart depicts remarkable similarity with developing fetal heart. Elucidating genetic as well as epigenetic mechanisms regulating the gene expression during cardiac development will improve our understanding of cardiovascular diseases.… read more here.

Keywords: functional annotation; fetal cardiac; differentially expressed; gene ... See more keywords
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Systematic Functional Annotation of Somatic Mutations in Cancer.

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recommendations! Published in 2018 at "Cancer cell"

DOI: 10.1016/j.ccell.2018.01.021

Abstract: The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision oncology. Here, we report the development of a moderate-throughput functional genomic platform consisting of… read more here.

Keywords: functional annotation; annotation somatic; somatic mutations; mutations cancer ... See more keywords

Functional annotation of operome from Methanothermobacter thermautotrophicus ΔH: An insight to metabolic gap filling.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.11.100

Abstract: Methanothermobacter thermautotrophicus ΔH (MTH) is a potential methanogen known to reduce CO2 with H2 for producing methane biofuel in thermophilic digesters. The genome of this organism contains ~50.5% conserved hypothetical proteins (HPs; operome) whose function… read more here.

Keywords: functional annotation; methanothermobacter thermautotrophicus; annotation operome;
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CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores

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recommendations! Published in 2019 at "Journal of Molecular Biology"

DOI: 10.1016/j.jmb.2019.06.003

Abstract: The control of ion channel permeation requires the modulation of energetic barriers or “gates” within their pores. However, such barriers are often simply identified from the physical dimensions of the pore. Such approaches have worked… read more here.

Keywords: ion channel; functional annotation; chap versatile; channel ... See more keywords

Functional annotation of the genome unravels probiotic potential of Bacillus coagulans HS243.

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recommendations! Published in 2018 at "Genomics"

DOI: 10.1016/j.ygeno.2018.05.022

Abstract: Spore forming Bacillus species are widely used as probiotics for human dietary supplements and in animal feeds. However, information on genetic basis of their probiotic action is obscure. Therefore, the present investigation was undertaken to… read more here.

Keywords: coagulans hs243; hs243 genome; functional annotation; genome ... See more keywords
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Functional Annotation of Chemical Libraries across Diverse Biological Processes

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recommendations! Published in 2017 at "Nature chemical biology"

DOI: 10.1038/nchembio.2436

Abstract: Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of action. We developed… read more here.

Keywords: annotation chemical; functional annotation; chemical genetic; biological processes ... See more keywords

In silico approaches for the identification of potential allergens among hypothetical proteins from Alternaria alternata and its functional annotation

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-55463-1

Abstract: Direct exposure to the fungal species Alternaria alternata is a major risk factor for the development of asthma, allergic rhinitis, and inflammation. As of November 23rd 2020, the NCBI protein database showed 11,227 proteins from… read more here.

Keywords: functional annotation; potential allergens; silico approaches; hypothetical proteins ... See more keywords

FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08651-2

Abstract: Protein functional annotation is crucial in biology, but many protein-coding genes remain uncharacterized, especially in non-model organisms. FANTASIA (Functional ANnoTAtion based on embedding space SImilArity) integrates protein language models for large-scale functional annotation. Applied to… read more here.

Keywords: functional annotation; biology; language; fantasia ... See more keywords

ProtPhage: a deep learning framework for phage viral protein identification and functional annotation

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recommendations! Published in 2025 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbaf285

Abstract: Abstract Phages, viruses that infect bacteria, offer a promising strategy against antibiotic-resistant pathogens. Phage viral proteins (PVPs) are essential for phage–host interactions, yet their identification and functional annotation remain challenging due to high sequence diversity,… read more here.

Keywords: deep learning; functional annotation; phage; identification functional ... See more keywords