MiRLog and dbmiR: Prioritization and functional annotation tools to study human microRNA sequence variants
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24399
Abstract: The recent identification of noncoding variants with pathogenic effects suggests that these variations could underlie a significant number of undiagnosed cases. Several computational methods have been developed to predict the functional impact of noncoding variants,… read more here.
Keywords: annotation tools; dbmir prioritization; mirlog dbmir; prioritization functional ... See more keywords
Functional Annotation of MicroRNAs Using Existing Resources.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1170-8_3
Abstract: MicroRNAs (miRNAs) are endogenous small noncoding RNAs that are involved in most biological signaling pathways, including the cell cycle, apoptosis, proliferation, immune response, metabolism as well as in biological processes including organ development and in… read more here.
Keywords: annotation micrornas; existing resources; functional annotation; biology ... See more keywords
Functional annotation of differentially expressed fetal cardiac microRNA targets: implication for microRNA-based cardiovascular therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1520-8
Abstract: Gene expression pattern of a failing heart depicts remarkable similarity with developing fetal heart. Elucidating genetic as well as epigenetic mechanisms regulating the gene expression during cardiac development will improve our understanding of cardiovascular diseases.… read more here.
Keywords: functional annotation; fetal cardiac; differentially expressed; gene ... See more keywords
Systematic Functional Annotation of Somatic Mutations in Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.01.021
Abstract: The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision oncology. Here, we report the development of a moderate-throughput functional genomic platform consisting of… read more here.
Keywords: functional annotation; annotation somatic; somatic mutations; mutations cancer ... See more keywords
Functional annotation of operome from Methanothermobacter thermautotrophicus ΔH: An insight to metabolic gap filling.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.11.100
Abstract: Methanothermobacter thermautotrophicus ΔH (MTH) is a potential methanogen known to reduce CO2 with H2 for producing methane biofuel in thermophilic digesters. The genome of this organism contains ~50.5% conserved hypothetical proteins (HPs; operome) whose function… read more here.
Keywords: functional annotation; methanothermobacter thermautotrophicus; annotation operome;
CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2019.06.003
Abstract: The control of ion channel permeation requires the modulation of energetic barriers or “gates” within their pores. However, such barriers are often simply identified from the physical dimensions of the pore. Such approaches have worked… read more here.
Keywords: ion channel; functional annotation; chap versatile; channel ... See more keywords
Functional annotation of the genome unravels probiotic potential of Bacillus coagulans HS243.
Sign Up to like & getrecommendations! Published in 2018 at "Genomics"
DOI: 10.1016/j.ygeno.2018.05.022
Abstract: Spore forming Bacillus species are widely used as probiotics for human dietary supplements and in animal feeds. However, information on genetic basis of their probiotic action is obscure. Therefore, the present investigation was undertaken to… read more here.
Keywords: coagulans hs243; hs243 genome; functional annotation; genome ... See more keywords
Functional Annotation of Chemical Libraries across Diverse Biological Processes
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2436
Abstract: Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of action. We developed… read more here.
Keywords: annotation chemical; functional annotation; chemical genetic; biological processes ... See more keywords
An improved ovine reference genome assembly to facilitate in-depth functional annotation of the sheep genome
Sign Up to like & getrecommendations! Published in 2022 at "GigaScience"
DOI: 10.1093/gigascience/giab096
Abstract: Abstract Background The domestic sheep (Ovis aries) is an important agricultural species raised for meat, wool, and milk across the world. A high-quality reference genome for this species enhances the ability to discover genetic mechanisms… read more here.
Keywords: reference genome; genome assembly; functional annotation; genome ... See more keywords
A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family
Sign Up to like & getrecommendations! Published in 2020 at "Glycobiology"
DOI: 10.1093/glycob/cwaa086
Abstract: Abstract The formation of β1,3-linkages on animal glycoconjugates is catalyzed by a subset of β1,3-glycosyltransferases grouped in the Carbohydrate-Active enZYmes family glycosyltransferase-31 (GT31). This family represents an extremely diverse set of β1,3-N-acetylglucosaminyltransferases [B3GNTs and Fringe… read more here.
Keywords: view functional; functional annotation; annotation animal; family ... See more keywords
From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac203
Abstract: The exponential accumulation of DNA sequencing data has opened new avenues for discovering the causative roles of single-nucleotide polymorphisms (SNPs) in neurological disease. The opportunities emerging from this are staggering, yet only as good as… read more here.
Keywords: bugs bedside; disease; functional annotation; invertebrate models ... See more keywords