What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a030262
Abstract: Functional antibodies, i.e., those with antipathogen activity in in vitro assays, are generally the best correlate of vaccine protection. Mimics of natural infection, including live attenuated and killed pathogens, which induce such antibodies in vivo,… read more here.
Keywords: functional antibodies; design vaccine; immunogen design; powerful immunogen ... See more keywords
Development of Functional Antibodies Directed to Human Dialyzable Leukocyte Extract (Transferon®)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/2754920
Abstract: Transferon® is an immunomodulator made of a complex mixture of peptides from human dialyzable leucocyte extracts (hDLEs). Development of surrogate antibodies directed to hDLE is an indispensable tool for studies during process control and preclinical… read more here.
Keywords: human dialyzable; functional antibodies; antibodies directed; development functional ... See more keywords
Functional antibodies against G-protein coupled receptors in Beagle dogs infected with two different strains of Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.926682
Abstract: The interaction of the anti-beta1-adrenergic receptor autoantibodies (β1ARAb) and the anti-muscarinic M2 receptor autoantibodies (M2RAb) with cardiac neurotransmitter receptors were identified in human chronic Chagas cardiomyopathy (CCC) related to the ECG and dysautonomia disturbances. Dogs… read more here.
Keywords: trypanosoma cruzi; functional antibodies; beagle dogs; dogs infected ... See more keywords
Antibody Libraries as Tools to Discover Functional Antibodies and Receptor Pleiotropism
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084123
Abstract: Most antibodies currently in use have been selected based on their binding affinity. However, nowadays, antibodies that can not only bind but can also alter the function of cell surface signaling components are increasingly sought… read more here.
Keywords: tools discover; functional antibodies; antibody libraries; antibody ... See more keywords
Differential Dynamics of SARS-CoV-2 Binding and Functional Antibodies upon BNT162b2 Vaccine: A 6-Month Follow-Up
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020312
Abstract: To investigate the dynamic association among binding and functional antibodies in health-care-workers receiving two doses of BNT162b2 mRNA COVID-19-vaccine, SARS-CoV-2 anti-RBD IgG, anti-Trimeric-S IgG, and neutralizing antibodies (Nabs) were measured in serum samples collected at… read more here.
Keywords: igg; trimeric igg; binding functional; functional antibodies ... See more keywords