An in vitro functional assay to measure the biological activity of TB vaccine candidate H4-IC31.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.04.035
Abstract: Potency assays for vaccine products are an important regulatory requirement, and are used to assess product quality and consistency prior to lot release for clinical testing. Ideally they measure an established correlate of efficacy or… read more here.
Keywords: ic31; vaccine candidate; measure; candidate ic31 ... See more keywords
Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac252
Abstract: Haploinsufficiency of TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2 (TAB2) has been associated with congenital heart disease and more recently multiorgan structural abnormalities. Missense variant represents a major proportion of non-synonymous TAB2 variants reported… read more here.
Keywords: disease; tab2 variants; pathogenicity; tab2 ... See more keywords
Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-0203
Abstract: Abstract Purpose: The identification of variants of uncertain significance (VUS) in the BRCA1 and BRCA2 genes by hereditary cancer testing poses great challenges for the clinical management of variant carriers. The ACMG/AMP (American College of… read more here.
Keywords: vus; classification; brca2; acmg amp ... See more keywords
Development of an In Vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin.
Sign Up to like & getrecommendations! Published in 2023 at "Skin pharmacology and physiology"
DOI: 10.1159/000529630
Abstract: INTRODUCTION Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the… read more here.
Keywords: skin; evaluate occlusive; development; dry skin ... See more keywords
High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing
Sign Up to like & getrecommendations! Published in 2022 at "ERJ Open Research"
DOI: 10.1183/23120541.00495-2022
Abstract: Background Cystic fibrosis (CF) is a rare hereditary disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Recent therapies enable effective restoration of CFTR function of the most common F508del CFTR… read more here.
Keywords: cftr; functional assay; patient derived; drug ... See more keywords