Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.12.002
Abstract: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prevent the… read more here.
Keywords: musk activation; benefit; kinase; functional benefit ... See more keywords
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20220045
Abstract: Measles, Nipah and Hendra viruses are severe human pathogens within the Paramyxoviridae family. Their non-segmented, single-stranded, negative-sense RNA genome is encapsidated by the nucleoprotein (N) within a helical nucleocapsid that is the substrate used by… read more here.
Keywords: functional benefit; hendra viruses; replication; measles nipah ... See more keywords
Lung segmentectomy: does it offer a real functional benefit over lobectomy?
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Review"
DOI: 10.1183/16000617.0079-2017
Abstract: Anatomical segmentectomy has been developed to offer better pulmonary function preservation than lobectomy, in stage IA lung cancer. Despite the retrospective nature of most of the studies and the lack of randomised studies, a substantial… read more here.
Keywords: segmentectomy; lobectomy; functional benefit; lung function ... See more keywords
Predictors of functional benefit of hepatitis C therapy in a ‘real-life’ cohort
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v24.i7.852
Abstract: AIM To define predictors of functional benefit of direct-acting antivirals (DAAs) in patients with chronic hepatitis C virus (HCV) infection and liver cirrhosis. METHODS We analysed a cohort of 199 patients with chronic HCV genotype… read more here.
Keywords: predictors functional; benefit; functional benefit; genotype infection ... See more keywords