Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization
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DOI: 10.1007/s11357-024-01334-6
Abstract: An increasing burden of neurological diseases (NDs) has been a public health challenge in an aging society. Age, especially biological age, is the most important risk factor for NDs. Identification of biomarkers of aging to… read more here.
Keywords: biomarkers aging; neurological diseases; risk; functional biomarkers ... See more keywords
Advancing epigenetic signatures as functional biomarkers in rare diseases.
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DOI: 10.1080/17501911.2025.2583891
Abstract: Alterations of the DNA methylation (DNAm) status of the genome underlie an increasing number of rare diseases. Recently, DNAm has also emerged as a highly informative biomarker for diagnosing rare disorders, which can be associated… read more here.
Keywords: rare diseases; genome wide; dnam; functional biomarkers ... See more keywords
Integrating Omics into Functional Biomarkers of Type 1 Diabetes.
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DOI: 10.1101/cshperspect.a041602
Abstract: Biomarkers are critical to the staging and diagnosis of type 1 diabetes (T1D). Functional biomarkers offer insights into T1D immunopathogenesis and are often revealed using "omics" approaches that integrate multiple measures to identify involved pathways… read more here.
Keywords: biomarkers type; integrating omics; omics functional; type diabetes ... See more keywords
Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden
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DOI: 10.1111/acel.14132
Abstract: Antihypertensive, lipid‐lowering, and blood glucose‐lowering drugs have slowed down the aging process in animal models. In humans, studies are limited, have short follow‐up times, and show mixed results. Therefore, this study aimed to estimate the… read more here.
Keywords: biomarkers aging; functional biomarkers; medications functional; index ... See more keywords
Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment
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DOI: 10.1186/s12943-025-02298-7
Abstract: MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of circulating miRNAs may parallel the cellular composition… read more here.
Keywords: circulating micrornas; functional biomarkers; biomarkers melanoma; melanoma prognosis ... See more keywords
Functional biomarkers of homologous repair (HR) deficiency to guide novel DNA damage response targeted therapy in clear cell renal cell carcinoma (ccRCC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4576
Abstract: 4576Background: Treatment for advanced ccRCC has rapidly evolved; however, responses are not uniform and synthetic lethal treatments with associated predictive biomarkers are still lacking. We prev... read more here.
Keywords: homologous repair; repair deficiency; biomarkers homologous; functional biomarkers ... See more keywords