FcγRIIIA affinity chromatography complements conventional functional characterization of rituximab
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3304
Abstract: Analytical and functional characterization of batches of biologics/biosimilar products are imperative towards qualifying them for pre‐clinical and clinical investigations. Several orthogonal strategies are employed to characterize the functional attributes of these drugs. However, the use… read more here.
Keywords: affinity chromatography; chromatography; riiia affinity; functional characterization ... See more keywords
Functional characterization of novel NR5A1 variants reveals multiple complex roles in disorders of sex development
Sign Up to like & getrecommendations! Published in 2018 at "Human Mutation"
DOI: 10.1002/humu.23354
Abstract: Variants in the NR5A1 gene encoding SF1 have been described in a diverse spectrum of disorders of sex development (DSD). Recently, we reported the use of a targeted gene panel for DSD where we identified… read more here.
Keywords: novel; functional characterization; sex development; nr5a1 variants ... See more keywords
Expression and functional characterization of missense mutations in ATP8A2 linked to severe neurological disorders
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23889
Abstract: ATP8A2 is a P4‐ATPase (adenosine triphosphate) that actively flips phosphatidylserine and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflet of cell membranes to generate and maintain phospholipid asymmetry. Mutations in the ATP8A2 gene have been… read more here.
Keywords: expression functional; functional characterization; missense mutations; atpase activity ... See more keywords
Functional characterization of a novel arachidonic acid 12S‐lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns
Sign Up to like & getrecommendations! Published in 2018 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.775
Abstract: Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed. In bacteria, lipoxygenases rarely occur and… read more here.
Keywords: lipoxygenase; arachidonic acid; functional characterization; myxococcus fulvus ... See more keywords
Functional characterization and clinical significance of super‐enhancers in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23419
Abstract: Super‐enhancers (SEs) are important transcriptional regulators in tumorigenesis; however, the functional characterization and clinical significance of SEs in lung adenocarcinoma (LUAD) remain unclear. By using H3K27ac ChIP‐seq data of two LUAD cell lines and eight… read more here.
Keywords: functional characterization; clinical significance; characterization clinical; super enhancers ... See more keywords
Structural and functional characterization of a novel acidophilic 7α‐hydroxysteroid dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3599
Abstract: 7α‐Hydroxysteroid dehydrogenase (7α‐HSDH) is an NAD(P)H‐dependent oxidoreductase belonging to the short‐chain dehydrogenases/reductases. In vitro, 7α‐HSDH is involved in the efficient biotransformation of taurochenodeoxycholic acid (TCDCA) to tauroursodeoxycholic acid (TUDCA). In this study, a gene encoding… read more here.
Keywords: characterization novel; dehydrogenase; functional characterization; structural functional ... See more keywords
Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_12
Abstract: Schistosomiasis caused by parasitic blood flukes of the genus Schistosoma is a global health problem with over 200 million people infected. Schistosoma mansoni cathepsin B1 (SmCB1) is a gut-associated protease critical for digestion of host blood… read more here.
Keywords: functional characterization; smcb1; structural functional; schistosoma mansoni ... See more keywords
Isolation and Functional Characterization of Fusobacterium nucleatum Bacteriophage.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1518-8_4
Abstract: Bacteriophages are viruses that specifically lyse bacteria. They have demonstrated potential in applications as antibacterial agents in medicine, agriculture, and environmental remediation. Due to the complex and dynamic nature of the oral microbiome, antibiotic treatment… read more here.
Keywords: fusobacterium nucleatum; functional characterization; bacteriophage; characterization fusobacterium ... See more keywords
ncRNA Editing: Functional Characterization and Computational Resources.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8982-9_6
Abstract: Noncoding RNAs (ncRNAs) have received much attention due to their central role in gene expression and translational regulation as well as due to their involvement in several biological processes and disease development. Small noncoding RNAs… read more here.
Keywords: ncrna editing; editing functional; functional characterization; characterization computational ... See more keywords
Functional characterization of a novel thermophilic exo-arabinanase from Thermothielavioides terrestris
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10806-6
Abstract: Arabinanases from glycoside hydrolase family GH93 are enzymes with exo-activity that hydrolyze the α-1,5 bonds between arabinose residues present on arabinan. Currently, several initiatives aiming to use byproducts rich in arabinan such as pectin and… read more here.
Keywords: characterization novel; thermothielavioides terrestris; exo arabinanase; functional characterization ... See more keywords
Evolutionary and functional characterization of leucoanthocyanidin reductases from Camellia sinensis
Sign Up to like & getrecommendations! Published in 2017 at "Planta"
DOI: 10.1007/s00425-017-2771-z
Abstract: AbstractMain conclusionLARs promoted the biosynthesis of catechin monomers and inhibited their polymerization. The accumulation of catechin monomers and polymers was increased by up-regulating the expression ofNtLARandNtANRs in CsMYB5b transgenic tobacco. Tea is rich in polyphenolic… read more here.
Keywords: leucoanthocyanidin; functional characterization; biosynthesis; catechin monomers ... See more keywords