Emerging therapies for HBsAg seroclearance: spotlight on novel combination strategies
Sign Up to like & getrecommendations! Published in 2025 at "Hepatology International"
DOI: 10.1007/s12072-025-10828-0
Abstract: Functional cure is a favorable endpoint in chronic hepatitis B (CHB), yet it is rarely achieved with currently approved drugs (nucleos[t]ide analogues and pegylated interferon alpha). A range of novel agents, broadly classified into virus-targeting… read more here.
Keywords: functional cure; treatment; combination; emerging therapies ... See more keywords
HBsAg, Subviral Particles, and Their Clearance in Establishing a Functional Cure of Chronic Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00638
Abstract: In diverse viral infections, the production of excess viral particles containing only viral glycoproteins (subviral particles or SVP) is commonly observed and is a commonly evolved mechanism for immune evasion. In hepatitis B virus (HBV)… read more here.
Keywords: functional cure; hepatitis virus; infection; subviral particles ... See more keywords
HBV cccDNA—A Culprit and Stumbling Block for the Hepatitis B Virus Infection: Its Presence in Hepatocytes Perplexed the Possible Mission for a Functional Cure
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02216
Abstract: Hepatitis B virus infection (HBV) is still a big health problem across the globe. It has been linked to the development of liver cirrhosis and hepatocellular carcinoma and can trigger different types of liver damage.… read more here.
Keywords: functional cure; hbv; hepatitis virus; biology ... See more keywords
Assessing the developing pharmacotherapeutic landscape in hepatitis B treatment: a spotlight on drugs in phase II clinical trials
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DOI: 10.1080/14728214.2022.2074977
Abstract: ABSTRACT Introduction Functional cure, defined as sustained HBsAg seroclearance, is associated with favorable outcomes in chronic hepatitis B (CHB). While nucleos(t)ide analogues (NAs) are effective in suppressing HBV replication, NAs are unable to induce functional… read more here.
Keywords: functional cure; hbv antivirals; induce functional; hepatitis ... See more keywords
Shedding light on RNaseH: a promising target for hepatitis B virus (HBV)
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1619697
Abstract: HBV is a hepatotropic DNA virus that replicates by reverse transcription [1]. The virus is genetically diverse, with at least 8 genotypes that differ by ~8% at the amino acid level. It chronically infects about… read more here.
Keywords: functional cure; dna; hepatitis; hbv ... See more keywords
Finite nucleos(t)ide-analogue therapy for functional cure in HBeAg-negative chronic hepatitis B: recent development in the paradigm shift.
Sign Up to like & getrecommendations! Published in 2024 at "Hepatology"
DOI: 10.1097/hep.0000000000001107
Abstract: Long-term nucleos(t)ide analogue (Nuc) therapy in chronic hepatitis B (CHB) may lead to hepatitis B virus (HBV) suppression, alanine aminotransferase (ALT) normalization, improvement of histological lesions, and prevention of liver disease progression, but rarely achieve… read more here.
Keywords: hbeag negative; functional cure; nuc therapy; therapy ... See more keywords
Roadmap to functional cure of chronic hepatitis B: An expert consensus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13126
Abstract: Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long‐term outcome, and is considered to be a ‘functional cure’ (also referred… read more here.
Keywords: cure chronic; expert consensus; hepatitis; chronic hepatitis ... See more keywords
Lower frequency of MDSCs was significantly related to functional cure in CHB patients treated with peginterferon
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15489
Abstract: Myeloid‐derived suppressor cells (MDSCs) and CD4+ regulatory T cells (Tregs) expand during chronic hepatitis B virus (HBV) infection and inhibit antiviral immunity. However, the relationship between antiviral effect and the frequencies of those immune suppressive… read more here.
Keywords: mdscs significantly; pegifn therapy; functional cure; frequency mdscs ... See more keywords
Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B patients.
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DOI: 10.1172/jci.insight.122268
Abstract: BACKGROUND The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients with chronic hepatitis B (CH). To understand the immune responses underlying functional cure, we evaluated… read more here.
Keywords: surface antigen; hepatitis; cytokine chemokine; hepatitis surface ... See more keywords
Towards HBV functional cure - do we have a crystal ball for that? - Authors' reply.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and molecular hepatology"
DOI: 10.3350/cmh.2022.0410
Abstract: recent paper on the role of early on-treatment decline in viral biomarkers in predicting favourable HBsAg response in chronic hepatitis B infection, published in Clinical and Molecular Hepatology . We agree with Liang and co-authors… read more here.
Keywords: hbv functional; functional cure; cure crystal; towards hbv ... See more keywords
Determinants of functional cure in interferon-treated chronic hepatitis B: a retrospective cohort analysis of HBsAg dynamics and clinical predictors
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2025.1615327
Abstract: Background and Objectives Functional cure of chronic hepatitis B (CHB) is the optimal goal of antiviral therapy. This study evaluates the functional cure rates in a large cohort treated with interferon (IFNα) and explores baseline… read more here.
Keywords: functional cure; cure; analysis; chronic hepatitis ... See more keywords