HBsAg, Subviral Particles, and Their Clearance in Establishing a Functional Cure of Chronic Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00638
Abstract: In diverse viral infections, the production of excess viral particles containing only viral glycoproteins (subviral particles or SVP) is commonly observed and is a commonly evolved mechanism for immune evasion. In hepatitis B virus (HBV)… read more here.
Keywords: functional cure; hepatitis virus; infection; subviral particles ... See more keywords
HBV cccDNA—A Culprit and Stumbling Block for the Hepatitis B Virus Infection: Its Presence in Hepatocytes Perplexed the Possible Mission for a Functional Cure
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02216
Abstract: Hepatitis B virus infection (HBV) is still a big health problem across the globe. It has been linked to the development of liver cirrhosis and hepatocellular carcinoma and can trigger different types of liver damage.… read more here.
Keywords: functional cure; hbv; hepatitis virus; biology ... See more keywords
Assessing the developing pharmacotherapeutic landscape in hepatitis B treatment: a spotlight on drugs in phase II clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Emerging Drugs"
DOI: 10.1080/14728214.2022.2074977
Abstract: ABSTRACT Introduction Functional cure, defined as sustained HBsAg seroclearance, is associated with favorable outcomes in chronic hepatitis B (CHB). While nucleos(t)ide analogues (NAs) are effective in suppressing HBV replication, NAs are unable to induce functional… read more here.
Keywords: functional cure; hbv antivirals; induce functional; hepatitis ... See more keywords
Shedding light on RNaseH: a promising target for hepatitis B virus (HBV)
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1619697
Abstract: HBV is a hepatotropic DNA virus that replicates by reverse transcription [1]. The virus is genetically diverse, with at least 8 genotypes that differ by ~8% at the amino acid level. It chronically infects about… read more here.
Keywords: functional cure; dna; hepatitis; hbv ... See more keywords
Roadmap to functional cure of chronic hepatitis B: An expert consensus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13126
Abstract: Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long‐term outcome, and is considered to be a ‘functional cure’ (also referred… read more here.
Keywords: cure chronic; expert consensus; hepatitis; chronic hepatitis ... See more keywords
Lower frequency of MDSCs was significantly related to functional cure in CHB patients treated with peginterferon
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15489
Abstract: Myeloid‐derived suppressor cells (MDSCs) and CD4+ regulatory T cells (Tregs) expand during chronic hepatitis B virus (HBV) infection and inhibit antiviral immunity. However, the relationship between antiviral effect and the frequencies of those immune suppressive… read more here.
Keywords: mdscs significantly; pegifn therapy; functional cure; frequency mdscs ... See more keywords
Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B patients.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.122268
Abstract: BACKGROUND The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients with chronic hepatitis B (CH). To understand the immune responses underlying functional cure, we evaluated… read more here.
Keywords: surface antigen; hepatitis; cytokine chemokine; hepatitis surface ... See more keywords
Towards HBV functional cure - do we have a crystal ball for that? - Authors' reply.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and molecular hepatology"
DOI: 10.3350/cmh.2022.0410
Abstract: recent paper on the role of early on-treatment decline in viral biomarkers in predicting favourable HBsAg response in chronic hepatitis B infection, published in Clinical and Molecular Hepatology . We agree with Liang and co-authors… read more here.
Keywords: hbv functional; functional cure; cure crystal; towards hbv ... See more keywords
Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1067362
Abstract: Objective To explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in hepatitis B e envelope antigen (HBeAg)-positive patients with chronic… read more here.
Keywords: functional cure; hbeag; therapy; hepatitis ... See more keywords
Study on the Retreatment, Outcome, and Potential Predictors of Recurrence in Patients With Recurrence of Hepatitis B After Functional Cure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879835
Abstract: Background Studies about the retreatment and predictors for patients with hepatitis B recurrence after functional cure are rare. This study aimed to evaluate the effect of retreatment, outcome, and potential predictors of recurrence in patients… read more here.
Keywords: functional cure; recurrence; predictors recurrence; peg ifn ... See more keywords
Expression of Functional Molecule on Plasmacytoid Dendritic Cells Is Associated With HBsAg Loss in HBeAg-Positive Patients During PEG-IFN α-2a Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.891424
Abstract: Objective The ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic… read more here.
Keywords: hbsag loss; functional cure; cure; peg ifn ... See more keywords