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1
Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00638
Abstract: In diverse viral infections, the production of excess viral particles containing only viral glycoproteins (subviral particles or SVP) is commonly observed and is a commonly evolved mechanism for immune evasion. In hepatitis B virus (HBV)…
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Keywords:
functional cure;
hepatitis virus;
infection;
subviral particles ... See more keywords
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2
Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02216
Abstract: Hepatitis B virus infection (HBV) is still a big health problem across the globe. It has been linked to the development of liver cirrhosis and hepatocellular carcinoma and can trigger different types of liver damage.…
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Keywords:
functional cure;
hbv;
hepatitis virus;
biology ... See more keywords
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1
Published in 2022 at "Expert Opinion on Emerging Drugs"
DOI: 10.1080/14728214.2022.2074977
Abstract: ABSTRACT Introduction Functional cure, defined as sustained HBsAg seroclearance, is associated with favorable outcomes in chronic hepatitis B (CHB). While nucleos(t)ide analogues (NAs) are effective in suppressing HBV replication, NAs are unable to induce functional…
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Keywords:
functional cure;
hbv antivirals;
induce functional;
hepatitis ... See more keywords
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1
Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1619697
Abstract: HBV is a hepatotropic DNA virus that replicates by reverse transcription [1]. The virus is genetically diverse, with at least 8 genotypes that differ by ~8% at the amino acid level. It chronically infects about…
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Keywords:
functional cure;
dna;
hepatitis;
hbv ... See more keywords
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1
Published in 2019 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13126
Abstract: Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long‐term outcome, and is considered to be a ‘functional cure’ (also referred…
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Keywords:
cure chronic;
expert consensus;
hepatitis;
chronic hepatitis ... See more keywords
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1
Published in 2022 at "Liver International"
DOI: 10.1111/liv.15489
Abstract: Myeloid‐derived suppressor cells (MDSCs) and CD4+ regulatory T cells (Tregs) expand during chronic hepatitis B virus (HBV) infection and inhibit antiviral immunity. However, the relationship between antiviral effect and the frequencies of those immune suppressive…
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Keywords:
mdscs significantly;
pegifn therapy;
functional cure;
frequency mdscs ... See more keywords
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0
Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.122268
Abstract: BACKGROUND The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients with chronic hepatitis B (CH). To understand the immune responses underlying functional cure, we evaluated…
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Keywords:
surface antigen;
hepatitis;
cytokine chemokine;
hepatitis surface ... See more keywords
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1
Published in 2022 at "Clinical and molecular hepatology"
DOI: 10.3350/cmh.2022.0410
Abstract: recent paper on the role of early on-treatment decline in viral biomarkers in predicting favourable HBsAg response in chronic hepatitis B infection, published in Clinical and Molecular Hepatology . We agree with Liang and co-authors…
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Keywords:
hbv functional;
functional cure;
cure crystal;
towards hbv ... See more keywords
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1
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1067362
Abstract: Objective To explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in hepatitis B e envelope antigen (HBeAg)-positive patients with chronic…
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Keywords:
functional cure;
hbeag;
therapy;
hepatitis ... See more keywords
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2
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879835
Abstract: Background Studies about the retreatment and predictors for patients with hepatitis B recurrence after functional cure are rare. This study aimed to evaluate the effect of retreatment, outcome, and potential predictors of recurrence in patients…
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Keywords:
functional cure;
recurrence;
predictors recurrence;
peg ifn ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.891424
Abstract: Objective The ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic…
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Keywords:
hbsag loss;
functional cure;
cure;
peg ifn ... See more keywords