Chemosensitivity‐Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum‐Acridine Anticancer Agent
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DOI: 10.1002/cmdc.202200331
Abstract: NCI‐60 growth inhibition and gene expression profiles were analyzed using Pearson correlation and functional enrichment computational tools to demonstrate critical mechanistic differences between a nucleolus‐targeting platinum‐acridine anticancer agent (PA) and other DNA‐directed chemotherapies. The results… read more here.
Keywords: functional enrichment; agent; platinum acridine; gene expression ... See more keywords
reString: an open-source Python software to perform automatic functional enrichment retrieval, results aggregation and data visualization
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DOI: 10.1038/s41598-021-02528-0
Abstract: Functional enrichment analysis is an analytical method to extract biological insights from gene expression data, popularized by the ever-growing application of high-throughput techniques. Typically, expression profiles are generated for hundreds to thousands of genes/proteins from… read more here.
Keywords: restring open; source python; functional enrichment; software ... See more keywords
Abstract 882: Functional enrichment analysis of somatic mutations identifies novel risk factors for pediatric neuroblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-882
Abstract: Pediatric neuroblastoma is among the most common solid tumors in children and accounts for approximately 15% of childhood cancer mortalities. Neuroblastomas are highly heterogeneous cancers, and few common genetic alterations are currently associated with neuroblastoma… read more here.
Keywords: pediatric neuroblastoma; altered survival; enrichment analysis; functional enrichment ... See more keywords
BUFET: boosting the unbiased miRNA functional enrichment analysis using bitsets
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DOI: 10.1186/s12859-017-1812-8
Abstract: BackgroundA group of miRNAs can regulate a biological process by targeting genes involved in the process. The unbiased miRNA functional enrichment analysis is the most precise in silico approach to predict the biological processes that… read more here.
Keywords: enrichment analysis; mirna functional; unbiased mirna; functional enrichment ... See more keywords
NetGen: a novel network-based probabilistic generative model for gene set functional enrichment analysis
Sign Up to like & getrecommendations! Published in 2017 at "BMC Systems Biology"
DOI: 10.1186/s12918-017-0456-7
Abstract: BackgroundHigh-throughput experimental techniques have been dramatically improved and widely applied in the past decades. However, biological interpretation of the high-throughput experimental results, such as differential expression gene sets derived from microarray or RNA-seq experiments, is… read more here.
Keywords: enrichment analysis; gene; network; functional enrichment ... See more keywords
Urgent need for consistent standards in functional enrichment analysis
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DOI: 10.1371/journal.pcbi.1009935
Abstract: Gene set enrichment tests (a.k.a. functional enrichment analysis) are among the most frequently used methods in computational biology. Despite this popularity, there are concerns that these methods are being applied incorrectly and the results of… read more here.
Keywords: gene; enrichment analysis; functional enrichment; need ... See more keywords
GOCompare: An R package to compare functional enrichment analysis between two species.
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DOI: 10.2139/ssrn.4201186
Abstract: Functional enrichment analysis is a cornerstone in bioinformatics as it makes possible to identify functional information by using a gene list as source. Different tools are available to compare gene ontology (GO) terms, based on… read more here.
Keywords: functional information; enrichment analysis; functional enrichment; gocompare package ... See more keywords
Functional Enrichment Analysis of Regulatory Elements
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DOI: 10.3390/biomedicines10030590
Abstract: Statistical methods for enrichment analysis are important tools to extract biological information from omics experiments. Although these methods have been widely used for the analysis of gene and protein lists, the development of high-throughput technologies… read more here.
Keywords: analysis; enrichment analysis; information; analysis regulatory ... See more keywords
Structural and Functional Enrichment Analyses for Antimicrobial Peptides
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DOI: 10.3390/ijms21228783
Abstract: Whether there is any inclination between structures and functions of antimicrobial peptides (AMPs) is a mystery yet to be unraveled. AMPs have various structures associated with many different antimicrobial functions, including antibacterial, anticancer, antifungal, antiparasitic… read more here.
Keywords: functional enrichment; enrichment; analyses antimicrobial; structural functional ... See more keywords