Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss‐of‐function phenotypes in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12309
Abstract: Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as recessive HADH mutations cause congenital… read more here.
Keywords: functional evaluation; missense variants; evaluation schad; hyperinsulinism infancy ... See more keywords
Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages?
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-018-1104-x
Abstract: AbstractSheep model is the most favourable choice for animal study for functional evaluation of the cervical fusion prostheses before clinical application; however, significantly large differences between sheep and human existed in terms of morphological characteristics… read more here.
Keywords: functional evaluation; sheep model; model; evaluation cervical ... See more keywords
An identification and functional evaluation of a novel CYP2C9 variant CYP2C9*62.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109168
Abstract: Warfarin is the most commonly used anticoagulant in the clinical treatment of thromboembolic diseases. The dose of warfarin varies significantly within populations, and the dose is closely related to the genetic polymorphisms of the CYP2C9… read more here.
Keywords: functional evaluation; evaluation novel; identification functional; cyp2c9 ... See more keywords
Functional Evaluation of a Novel Microwave Surgical Device in a Canine Splenectomy Model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2019.1619884
Abstract: Abstract Aim: Partial splenectomy remains a difficult procedure even with the assistance of a sealing system. Recently, a scissor-like microwave energy device (Acrosurg) that provides seamless coagulation and manual cutting has been applied in surgery.… read more here.
Keywords: splenectomy; functional evaluation; manual cutting; group ... See more keywords
Rapid but not Harmful: Functional Evaluation With Hepatobiliary Scintigraphy After Accelerated Liver Regeneration Techniques.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003184
Abstract: 1. Bannone E, Andrianello S, Marchegiani G, et al. Postoperative acute pancreatitis following pancreaticoduodenectomy: a determinant of fistula potentially driven by the intraoperative fluid management. Ann Surg. 2018;268:815–822. 2. Bassi C, Marchegiani G, Dervenis C,… read more here.
Keywords: fistula; surg; functional evaluation; harmful functional ... See more keywords
Non-Invasive Functional Evaluation of the Human Spinal Cord by Assessing the Peri-Spinal Neurovascular Network With Near Infrared Spectroscopy
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2021.3123587
Abstract: Current medical care lacks an effective functional evaluation for the spinal cord. Magnetic resonance imaging and computed tomography mainly provide structural information of the spinal cord, while spinal somatosensory evoked potentials are limited by a… read more here.
Keywords: spectroscopy; functional evaluation; peri spinal; non invasive ... See more keywords
Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.075317
Abstract: Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form… read more here.
Keywords: functional evaluation; nonsteroidal inhibitors; structural functional; p450 17a1 ... See more keywords
PO-033 Identification and functional evaluation of monoclonal antibodies specifically targeting human carbonic anhydrase IX
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.568
Abstract: Introduction Poor vascularisation of solid tumours leads to inadequate nutrient and oxygen supplies which forces tumour cells to reprogram their metabolism. As a consequence the tumour cell’s environment becomes acidic and hypoxic. This, in turn,… read more here.
Keywords: functional evaluation; carbonic anhydrase; 033 identification; monoclonal antibodies ... See more keywords
Abstract 90: In vitro functional evaluation of immuno-oncology drug candidates in customized bioassays
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-90
Abstract: Increased understanding of the complex tumor microenvironment and its interactors has boosted therapeutic interest and highlighted the importance of the development of innovative in vitro bioassays to represent all the players of the cancer immune… read more here.
Keywords: oncology; immuno oncology; cynomolgus macaque; functional evaluation ... See more keywords
Genomic and functional evaluation of exopolysaccharide produced by Liquorilactobacillus mali t6-52: technological implications
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Cell Factories"
DOI: 10.1186/s12934-024-02431-z
Abstract: Background This study explores the biosynthesis, characteristics, and functional properties of exopolysaccharide produced by the strain Liquorilactobacillus mali T6-52. The strain demonstrated significant EPS production with a non-ropy phenotype. Results The genomic analysis unveiled genes… read more here.
Keywords: exopolysaccharide produced; functional evaluation; liquorilactobacillus mali; functional properties ... See more keywords
Exercise tests in Chagas cardiomyopathy: an overview of functional evaluation, prognostic significance, and current challenges
Sign Up to like & getrecommendations! Published in 2020 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0100-2020
Abstract: Abstract Patients with Chagas cardiomyopathy (ChC) usually progress with fatigue and dyspnea. Exercise tests are valuable for the functional evaluation of these patients. However, information about the applicability of the exercise tests is scattered, and… read more here.
Keywords: functional evaluation; exercise tests; chagas cardiomyopathy; exercise ... See more keywords