Contrasting patterns of neutral and functional genetic diversity in stable and disturbed environments
Sign Up to like & getrecommendations! Published in 2018 at "Ecology and Evolution"
DOI: 10.1002/ece3.4667
Abstract: Abstract Genetic structure among and diversity within natural populations is influenced by a combination of ecological and evolutionary processes. These processes can differently influence neutral and functional genetic diversity and also vary according to environmental… read more here.
Keywords: functional genetic; diversity; genetic diversity; neutral functional ... See more keywords
Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1375
Abstract: The Oculo‐Auriculo‐Vertebral Spectrum (OAVS) or Goldenhar Syndrome is an embryonic developmental disorder characterized by hemifacial microsomia associated with auricular, ocular and vertebral malformations. The clinical heterogeneity of this spectrum and its incomplete penetrance limited the… read more here.
Keywords: functional genetic; provide evidences; genetic analyses; evidences involvement ... See more keywords
Characterization of microbial functional and genetic diversity as a novel strategy of biowaste ecotoxicological evaluation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Environmental Science and Technology"
DOI: 10.1007/s13762-018-2066-3
Abstract: The goal was to elucidate the importance of the waste properties for effective exploitation in biogas production and for soil application, respectively, based on the physicochemical and microbial characterization of biowaste and the corresponding biogas… read more here.
Keywords: functional genetic; biowaste; genetic diversity; ecotoxicological evaluation ... See more keywords
A functional and genetic overview of exopolysaccharides produced by Lactobacillus plantarum
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.05.060
Abstract: Abstract Lactobacillus plantarum strains have been widely used in food processing and preservation, and capability of their production of exopolysaccharides (EPSs) contributes significantly to the improvement of food quality and function. During the last decade,… read more here.
Keywords: plantarum strains; functional genetic; overview exopolysaccharides; genetic overview ... See more keywords
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01884-x
Abstract: ATM and ATR are conserved regulators of the DNA damage response linked to cancer. Comprehensive DNA sequencing efforts identified ~4,000 cancer-associated mutations in ATM/ATR; however, their cancer implications remain largely unknown. To gain insights, we… read more here.
Keywords: functional genetic; cancer genome; cancer; atm atr ... See more keywords
Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants.
Sign Up to like & getrecommendations! Published in 2021 at "Alcohol and alcoholism"
DOI: 10.1093/alcalc/agab031
Abstract: AIMS The study aimed to identify specific genes and functional genetic variants affecting susceptibility to two alcohol-related phenotypes: heavy drinking and problem drinking. METHODS Phenotypic and exome sequence data were downloaded from the UK Biobank.… read more here.
Keywords: drinking; functional genetic; problem drinking; genetic variants ... See more keywords
A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky539
Abstract: Abstract Riboswitches are structured mRNA sequences that regulate gene expression by directly binding intracellular metabolites. Generating the appropriate regulatory response requires the RNA rapidly and stably acquire higher-order structure to form the binding pocket, bind… read more here.
Keywords: functional genetic; cobalamin riboswitches; genetic screen; sequence ... See more keywords
Functional genetic diversity of domestic and wild American mink (Neovison vison)
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DOI: 10.1111/eva.13061
Abstract: The release of domestic organisms to the wild threatens biodiversity because the introduction of domestic genes through interbreeding can negatively impact wild conspecifics via outbreeding depression. In North America, farmed American mink (Neovison vison) frequently… read more here.
Keywords: functional genetic; mink neovison; american mink; mink ... See more keywords
PO-494 Using functional genetic screens to understand resistance to PARPi in BRCA-deficient tumours
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.511
Abstract: Introduction Error-free repair of double-strand DNA breaks is achieved by homologous recombination (HR), and both BRCA1 and BRCA2 are crucial for this process. Inactivating germline mutations of BRCA1 and BRCA2 genes predispose to breast and… read more here.
Keywords: functional genetic; deficient; parpi; resistance ... See more keywords
Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms
Sign Up to like & getrecommendations! Published in 2019 at "Biological Research For Nursing"
DOI: 10.1177/1099800419846407
Abstract: Incorporating biologically based data into symptom science research can contribute substantially to understanding commonly experienced symptoms across chronic conditions. The purpose of this literature review was to identify functional polymorphisms associated with common symptoms (i.e.,… read more here.
Keywords: symptom science; functional genetic; research; science ... See more keywords