The functional genomic studies of resveratrol in respect to its anti-cancer effects.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2018.02.011
Abstract: Resveratrol has anti-cancer effects in vitro, and hypothetical chemopreventive effects in vivo. Effects are pleiotropic, mediated by changes in expression of many genes and epigenetic reprogramming. Thus, they are well suited for functional genomic studies.… read more here.
Keywords: genomic studies; cancer effects; functional genomic; anti cancer ... See more keywords
The functional genomic studies of curcumin.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.04.002
Abstract: Curcumin is a natural plant-derived compound that has attracted a lot of attention for its anti-cancer activities. Curcumin can slow proliferation of and induce apoptosis in cancer cell lines, but the precise mechanisms of these… read more here.
Keywords: genomic studies; functional genomic; studies curcumin; cancer ... See more keywords
Learning a genome-wide score of human–mouse conservation at the functional genomics level
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22653-8
Abstract: Identifying genomic regions with functional genomic properties that are conserved between human and mouse is an important challenge in the context of mouse model studies. To address this, we develop a method to learn a… read more here.
Keywords: functional genomic; human mouse; score; conservation functional ... See more keywords
Multiplexed functional genomic assays to decipher the noncoding genome.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac194
Abstract: Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome complicates the identification of functional noncoding genetic variants and their causal association with disease. Current computational methods for variant prioritization have limited predictive value,… read more here.
Keywords: noncoding genetic; genomic assays; multiplexed functional; assays decipher ... See more keywords
A molecular toolkit to boost functional genomic studies in transformation-recalcitrant vegetable legumes
Sign Up to like & getrecommendations! Published in 2023 at "Horticulture Research"
DOI: 10.1093/hr/uhad064
Abstract: © The Author(s) 2023. Published by Oxford University Press on behalf of Nanjing Agricultural University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted… read more here.
Keywords: toolkit boost; genomic studies; horticulture; boost functional ... See more keywords
EPCO-11. IN VIVO FUNCTIONAL GENOMIC SCREEN IDENTIFIES WISP1 AS AN OVEREXPRESSED DRIVER OF GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.290
Abstract: There is a tremendous need to identify new genetic drivers of glioblastoma which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific in… read more here.
Keywords: driver; functional genomic; vivo functional; overexpressed driver ... See more keywords
A functional genomic approach to actionable gene fusions for precision oncology
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm2382
Abstract: Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes have been identified in patients with cancer, but the functional consequences and therapeutic implications of most of these remain largely unknown. Here,… read more here.
Keywords: functional genomic; oncology; genomic approach; gene fusions ... See more keywords
Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1509994
Abstract: The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autism phenotypes (BAP) offers a promising approach to the search for ASD candidate variants. Here, a total of 650,000 genetic markers were tested… read more here.
Keywords: multiplex autism; autism; analysis multiplex; genomic analysis ... See more keywords
Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00721
Abstract: Substance use disorders are prevalent and present a tremendous societal cost but the mechanisms underlying addiction behavior are poorly understood and few biological treatments exist. One strategy to identify novel molecular mechanisms of addiction is… read more here.
Keywords: locomotor; functional genomic; analysis; response cocaine ... See more keywords
Functional Genomic Analysis of Amphetamine Sensitivity in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.831597
Abstract: Abuse of psychostimulants, including amphetamines (AMPHs), is a major public health problem with profound psychiatric, medical, and psychosocial complications. The actions of these drugs at the dopamine transporter (DAT) play a critical role in their… read more here.
Keywords: analysis amphetamine; sensitivity; genomic analysis; functional genomic ... See more keywords