Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0322-164r
Abstract: Differences in the ability of neutrophils to perform relevant effector functions has been identified in a variety of disease states. Although neutrophil functional heterogeneity is increasingly recognized during disease, few studies have examined neutrophil functional… read more here.
Keywords: neutrophil functional; gene expression; functional heterogeneity; fixed phenotype ... See more keywords
Functional heterogeneity of CD4+ T cells in liver inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-021-00881-w
Abstract: CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to… read more here.
Keywords: heterogeneity cd4; functional heterogeneity; cd4 cells; inflammatory diseases ... See more keywords
Developmental and Functional Heterogeneity of Monocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.10.005
Abstract: Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of… read more here.
Keywords: heterogeneity; functional heterogeneity; heterogeneity monocytes; developmental functional ... See more keywords
Effect of culture medium and cell size on functional heterogeneity of canine adipose-derived mesenchymal stromal cells
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.130
Abstract: Background & Aim Introduction Mesenchymal stromal cells (MSCs) are being investigated in clinical trials for treatment of a variety of veterinary conditions based on their anti-inflammatory actions and potential to induce functional tissue repair. However,… read more here.
Keywords: functional heterogeneity; mesenchymal stromal; stromal cells; size ... See more keywords
Developmental and functional heterogeneity of thermogenic adipose tissue
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa029
Abstract: Abstract The obesity epidemic continues to rise as a global health challenge. Thermogenic brown and beige adipocytes dissipate chemical energy as heat, providing an opportunity for developing new therapeutics for obesity and related metabolic diseases.… read more here.
Keywords: thermogenic adipose; functional heterogeneity; tissue; heterogeneity thermogenic ... See more keywords
Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1484
Abstract: The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Employing single-cell RNA-sequencing, multiplex immunostaining, and several genetic mouse models, we identify carcinoma-associated… read more here.
Keywords: cafs; functional heterogeneity; carcinoma associated; associated fibroblasts ... See more keywords
Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17800
Abstract: The pancreatic stellate cell (PSC) is the principal cell type of the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence the progression of the disease through a complex network… read more here.
Keywords: tumor; functional heterogeneity; hgf; cancer cells ... See more keywords
Editorial: Functional heterogeneity of stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1179911
Abstract: Regulation of the functional activity of stem cells is extremely important for their coordinated action in the processes of tissue repair and regeneration, as well as maintenance of its homeostasis. We now understand that stem… read more here.
Keywords: functional heterogeneity; heterogeneity stem; stem cells; stem ... See more keywords
Editorial: Phenotypic and functional heterogeneity of neutrophils
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1195605
Abstract: COPYRIGHT © 2023 Tamassia and Jaillon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the… read more here.
Keywords: phenotypic functional; heterogeneity neutrophils; functional heterogeneity; editorial phenotypic ... See more keywords
Response of soil microbial compositional and functional heterogeneity to grazing exclusion in alpine shrub and meadows in the Qinghai–Tibet Plateau
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1038805
Abstract: Soil microorganisms found in shrub-meadow ecosystems are highly heterogeneous and extremely sensitive to grazing, but changes in microbial compositional and functional heterogeneity during grazing exclusion (GE) have been largely overlooked compared to community diversity. We… read more here.
Keywords: heterogeneity; metabolism; functional heterogeneity; compositional functional ... See more keywords
Satellite Glial Cells: Morphology, functional heterogeneity, and role in pain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1019449
Abstract: Neurons in the somatic, sympathetic, and parasympathetic ganglia are surrounded by envelopes consisting of satellite glial cells (SGCs). Recently, it has become clear that SGCs are highly altered after nerve injury, which influences neuronal excitability… read more here.
Keywords: functional heterogeneity; role; satellite glial; pain ... See more keywords