Aldh1L1 Lineage Cells Contribute to the Functional Heterogeneity Within the Cells in Glial Scars After Spinal Cord Injury Through YAP Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "Glia"
DOI: 10.1002/glia.70092
Abstract: Injury to the central nervous system (CNS) such as spinal cord results in multifaceted cellular responses, including the glial scars, a structural formation of reactive glia around an area of severe tissue damage. However, the… read more here.
Keywords: aldh1l1 lineage; functional heterogeneity; lineage cells; cells glial ... See more keywords
Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0322-164r
Abstract: Differences in the ability of neutrophils to perform relevant effector functions has been identified in a variety of disease states. Although neutrophil functional heterogeneity is increasingly recognized during disease, few studies have examined neutrophil functional… read more here.
Keywords: neutrophil functional; gene expression; functional heterogeneity; fixed phenotype ... See more keywords
Functional heterogeneity of CD4+ T cells in liver inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-021-00881-w
Abstract: CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to… read more here.
Keywords: heterogeneity cd4; functional heterogeneity; cd4 cells; inflammatory diseases ... See more keywords
Developmental and Functional Heterogeneity of Monocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.10.005
Abstract: Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of… read more here.
Keywords: heterogeneity; functional heterogeneity; heterogeneity monocytes; developmental functional ... See more keywords
Effect of culture medium and cell size on functional heterogeneity of canine adipose-derived mesenchymal stromal cells
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DOI: 10.1016/j.jcyt.2020.03.130
Abstract: Background & Aim Introduction Mesenchymal stromal cells (MSCs) are being investigated in clinical trials for treatment of a variety of veterinary conditions based on their anti-inflammatory actions and potential to induce functional tissue repair. However,… read more here.
Keywords: functional heterogeneity; mesenchymal stromal; stromal cells; size ... See more keywords
Developmental and functional heterogeneity of thermogenic adipose tissue
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DOI: 10.1093/jmcb/mjaa029
Abstract: Abstract The obesity epidemic continues to rise as a global health challenge. Thermogenic brown and beige adipocytes dissipate chemical energy as heat, providing an opportunity for developing new therapeutics for obesity and related metabolic diseases.… read more here.
Keywords: thermogenic adipose; functional heterogeneity; tissue; heterogeneity thermogenic ... See more keywords
Generation of Mammalian Astrocyte Functional Heterogeneity.
Sign Up to like & getrecommendations! Published in 2024 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041351
Abstract: Mammalian astrocytes have regional roles within the brain parenchyma. Indeed, the notion that astrocytes are molecularly heterogeneous could help explain how the central nervous system (CNS) retains embryonic positional information through development into specialized regions… read more here.
Keywords: generation mammalian; brain; functional heterogeneity; astrocyte functional ... See more keywords
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt3873
Abstract: Somatic mitochondrial DNA (mtDNA) mutations are frequently observed in tumors, yet their role in pediatric cancers remains poorly understood. The heteroplasmic nature of mtDNA—where mutant and wild-type mtDNA coexist—complicates efforts to define its contribution to… read more here.
Keywords: mtdna; leukemic cells; functional heterogeneity; source functional ... See more keywords
IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth
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DOI: 10.1136/gutjnl-2023-330390
Abstract: Background The elevation of IQGAP3 expression in diverse cancers indicates a key role for IQGAP3 in carcinogenesis. Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway,… read more here.
Keywords: malignant growth; iqgap3; enhance malignant; functional heterogeneity ... See more keywords
Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1484
Abstract: The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Employing single-cell RNA-sequencing, multiplex immunostaining, and several genetic mouse models, we identify carcinoma-associated… read more here.
Keywords: cafs; functional heterogeneity; carcinoma associated; associated fibroblasts ... See more keywords
Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17800
Abstract: The pancreatic stellate cell (PSC) is the principal cell type of the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence the progression of the disease through a complex network… read more here.
Keywords: tumor; functional heterogeneity; hgf; cancer cells ... See more keywords