Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00440-z
Abstract: Moment-to-moment adjustment of regional cerebral blood flow to neuronal activity via neurovascular coupling (NVC or "functional hyperemia") has a critical role in maintenance of healthy cognitive function. Aging-induced impairment of NVC responses importantly contributes to… read more here.
Keywords: nvc responses; abt263 navitoclax; treatment; aged mice ... See more keywords
Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice
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DOI: 10.1101/2020.12.16.422785
Abstract: Brain requires increased local cerebral blood flow (CBF) for as long as necessary during neuronal activation to match O2 and glucose supply with demand – termed functional hyperemia. Ca2+ elevation in astrocytes can drive arteriole… read more here.
Keywords: functional hyperemia; hyperemia; arteriole dilation; astrocyte ca2 ... See more keywords
Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15792
Abstract: Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a long-lasting vasoconstriction known as spreading oligemia. Further, cerebrovascular reactivity is reversibly impaired after SD.… read more here.
Keywords: functional hyperemia; nimodipine; spreading oligemia; nimodipine accelerates ... See more keywords