Structural and functional insights into RHA-P, a bacterial GH106 α-L-rhamnosidase from Novosphingobium sp. PP1Y.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.04.013
Abstract: α-L-Rhamnosidases (α-RHAs, EC 3.2.1.40) are glycosyl hydrolases (GHs) hydrolyzing terminal α-l-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the… read more here.
Keywords: natural flavonoids; functional insights; novosphingobium pp1y; structural functional ... See more keywords
Genetics of human autoimmunity: From genetic information to functional insights.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.08.017
Abstract: Genome-wide association studies have identified hundreds of risk variants associated with human autoimmune diseases. Recent evidence suggests that a substantial portion of them affect gene expression in specific cell types. To obtain the functional insights… read more here.
Keywords: human autoimmunity; genetics human; genetics; functional insights ... See more keywords
Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.028
Abstract: Enteropathogenic E. coli NleB and related type III effectors catalyze arginine GlcNAcylation of death domain (DD) proteins to block host defense, but the underlying mechanism is unknown. Here we solve crystal structures of NleB alone and… read more here.
Keywords: death; insights host; functional insights; arginine ... See more keywords
Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00273-5
Abstract: The cell surface of most Gram-negative bacteria contains lipopolysaccharide that is essential for their viability and drug resistance. A 134-kDa protein complex LptB2FG is unique among ATP-binding cassette transporters because it extracts lipopolysaccharide from the… read more here.
Keywords: functional insights; structural functional; transporter lptb2fg; membrane ... See more keywords
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Systems Biology"
DOI: 10.15252/msb.202210947
Abstract: Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell-type resolution to predict outcome and design therapy. Here, we quantify more than 150,000 sequence-unique peptides aggregated into 10,000 proteins across… read more here.
Keywords: cell; liver proteome; liver; functional insights ... See more keywords
Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery.
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.2210/pdb6jfy/pdb
Abstract: GluK3-kainate receptors are atypical members of the iGluR family that reside at both the pre- and postsynapse and play a vital role in the regulation of synaptic transmission. For a better understanding of structural changes… read more here.
Keywords: kainate receptor; receptor; functional insights; structural functional ... See more keywords
Physiological, Structural, and Functional Insights Into the Cryoprotection of Membranes by the Dehydrins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.886525
Abstract: Plants can be exposed to cold temperatures and have therefore evolved several mechanisms to prevent damage caused by freezing. One of the most important targets are membranes, which are particularly susceptible to cold damage. To… read more here.
Keywords: lea proteins; insights cryoprotection; functional insights; cryoprotection ... See more keywords
Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71)
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168757
Abstract: Enterovirus A71 (EV-A71) is a major neurovirulent agent capable of causing severe hand, foot and mouth disease (HFMD) associated with neurological complications and death. Currently, no FDA-approved antiviral is available for the treatment of EV-A71… read more here.
Keywords: enterovirus a71; agent; silymarin; a71 a71 ... See more keywords
Structural and Functional Insights into CP2c Transcription Factor Complexes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126369
Abstract: CP2c, also known as TFCP2, α-CP2, LSF, and LBP-1c, is a prototypic member of the transcription factor (TF) CP2 subfamily involved in diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies including cancer. Despite… read more here.
Keywords: cp2c; structural functional; transcription factor; functional insights ... See more keywords
Structural and functional insights of the human peroxisomal ABC transporter ALDP
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75039
Abstract: Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-long-chain fatty acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane. Dysfunction of ALDP leads to peroxisomal metabolic disorder exemplified by X-linked adrenoleukodystrophy (ALD). Hundreds of… read more here.
Keywords: functional insights; peroxisomal abc; insights human; abc transporter ... See more keywords