Comprehensive investigation of pathway enrichment methods for functional interpretation of LC-MS global metabolomics data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac553
Abstract: BACKGROUND Global or untargeted metabolomics is widely used to comprehensively investigate metabolic profiles under various pathophysiological conditions such as inflammations, infections, responses to exposures or interactions with microbial communities. However, biological interpretation of global metabolomics… read more here.
Keywords: enrichment methods; metabolomics data; pathway enrichment; functional interpretation ... See more keywords
Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac141
Abstract: Super enhancers (SEs) are broad enhancer domains usually containing multiple constituent enhancers that hold elevated activities in gene regulation. Disruption in one or more constituent enhancers causes aberrant SE activities that lead to gene dysregulation… read more here.
Keywords: internal dynamics; differential ses; functional interpretation; differential analysis ... See more keywords