Functional Maturation and In Vitro Differentiation of Neonatal Porcine Islet Grafts
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000002354
Abstract: Background There is a strong rationale to pursue the use of neonatal porcine islets (NPIs) as an unlimited source of islets for clinical xenotransplantation. Because NPIs are composed of immature insulin producing beta (ß) cells… read more here.
Keywords: neonatal porcine; vitro differentiation; differentiation; cell ... See more keywords
m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db19-0906
Abstract: The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in… read more here.
Keywords: methylation controls; m6a mrna; mrna methylation; maturation ... See more keywords
Cytokine Cocktail Promotes Alveolar Macrophage Reconstitution and Functional Maturation in a Murine Model of Haploidentical Bone Marrow Transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.719727
Abstract: Infectious pneumonia is one of the most common complications after bone marrow transplantation (BMT), which is considered to be associated with poor reconstitution and functional maturation of alveolar macrophages (AMs) post-transplantation. Here, we present evidence… read more here.
Keywords: marrow transplantation; reconstitution; transplantation; reconstitution functional ... See more keywords
IRF2 is required for development and functional maturation of human NK cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1038821
Abstract: Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes that play an important role in the first line of defense against malignant or virus-infected cells. A better understanding of the transcriptional regulation of human NK… read more here.
Keywords: cell; irf2; development functional; functional maturation ... See more keywords
Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042096
Abstract: The functional maturation of insulin-secreting β-cells is initiated before birth and is completed in early postnatal life. This process has a critical impact on the acquisition of an adequate functional β-cell mass and on the… read more here.
Keywords: cell; maturation; environment; functional maturation ... See more keywords