Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity
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DOI: 10.1002/advs.202412393
Abstract: Necroptosis plays a crucial role in the progression of various diseases and has gained substantial attention for its potential to activate antitumor immunity. However, the complex signaling networks that regulate necroptosis have made it challenging… read more here.
Keywords: therapeutic applications; immunity; optogenetically activatable; functional module ... See more keywords
A Network Hierarchy-Based method for functional module detection in protein-protein interaction networks.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.06.026
Abstract: In the post-genomic era, one of the important tasks is to identify protein complexes and functional modules from high-throughput protein-protein interaction data, so that we can systematically analyze and understand the molecular functions and biological… read more here.
Keywords: protein; detection; network; functional module ... See more keywords
MTGO: PPI Network Analysis Via Topological and Functional Module Identification
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23672-0
Abstract: Protein-protein interaction (PPI) networks are viable tools to understand cell functions, disease machinery, and drug design/repositioning. Interpreting a PPI, however, it is a particularly challenging task because of network complexity. Several algorithms have been proposed… read more here.
Keywords: network; ppi; via topological; functional module ... See more keywords