Predicting clinical benefit of immunotherapy by antigenic or functional mutations affecting tumour immunogenicity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14562-z
Abstract: Neoantigen burden is regarded as a fundamental determinant of response to immunotherapy. However, its predictive value remains in question because some tumours with high neoantigen load show resistance. Here, we investigate our patient cohort together… read more here.
Keywords: clinical benefit; immunotherapy; resistance; functional mutations ... See more keywords
Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002158
Abstract: Abstract The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is… read more here.
Keywords: implications viral; sars cov; mutations sars; functional mutations ... See more keywords