Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
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DOI: 10.1016/j.ejphar.2020.173169
Abstract: Chronic opioids treatment is impeded by the development of analgesic tolerance and opioid-induced hyperalgesia. Recent studies have shown that multi-functional opioid compounds produce analgesic activities with limited side effects. We developed a novel multi-functional peptide… read more here.
Keywords: tolerance; multi functional; functional opioid; opioid induced ... See more keywords