Cyclin D mediates tolerance of genome-doubling in cancers with functional p53
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DOI: 10.1093/annonc/mdw612
Abstract: Abstract Background Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 dysfunction, we… read more here.
Keywords: genome doubling; cyclin; functional p53; type ... See more keywords