KCNT2-related disorders: phenotypes, functional and pharmacological properties.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26662
Abstract: OBJECTIVE Pathogenic variants in KCNT2 are rare causes of developmental epileptic encephalopathy (DEE). We herein describe the phenotypic and genetic features of patients with KCNT2-related DEE, and the in vitro functional and pharmacological properties of… read more here.
Keywords: properties kcnt2; pharmacological properties; kcnt2 related; functional pharmacological ... See more keywords
Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01912-7
Abstract: Vesicular glutamate transporters (VGLUTs) control quantal size of glutamatergic transmission and have been the center of numerous studies over the past two decades. VGLUTs contain two independent transport modes that facilitate glutamate packaging into synaptic… read more here.
Keywords: structural functional; functional pharmacological; vesicular glutamate; molecular structural ... See more keywords
Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1014678
Abstract: The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human… read more here.
Keywords: dopamine receptor; role; functional pharmacological; d4r ... See more keywords