In vivo functional phenotypes from a computational epistatic model of evolution
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2308895121
Abstract: Significance The ability to observe viable step-wise changes to functional sequences evolved computationally from extant sequence data is a powerful tool. We developed a model of neutral evolution capable of preserving the statistics of observed… read more here.
Keywords: evolution; phenotypes computational; computational epistatic; functional phenotypes ... See more keywords
Letter by Vieira and Bocchi Regarding Article, "Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes: Insights From the UK Biobank Population Imaging Study".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.038033
Abstract: April 9, 2019 1857 Jefferson Luis Vieira, MD, PhD Edimar Alcides Bocchi, MD, PhD To the Editor: Based on data from the UK Biobank Population cohort, Aung et al1 provided a significant contribution to the… read more here.
Keywords: morpho functional; biobank population; population; functional phenotypes ... See more keywords
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1341752
Abstract: Purpose Sepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to… read more here.
Keywords: disease severity; sepsis patients; distinct functional; functional phenotypes ... See more keywords
Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00139
Abstract: Microglia are the resident innate immune cells of the central nervous system that mediate brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark shared by various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.… read more here.
Keywords: microglial phenotypes; modulation; pharmacological modulation; neurodegenerative diseases ... See more keywords
Functional Phenotypes of Intraplaque Macrophages and Their Distinct Roles in Atherosclerosis Development and Atheroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020452
Abstract: Macrophages are the key inflammatory cell type involved in all stages of atherosclerosis development and progression, as demonstrated by numerous studies. Correspondingly, macrophages are currently regarded as a promising therapeutic target for the development of… read more here.
Keywords: development; phenotypes intraplaque; macrophages distinct; intraplaque macrophages ... See more keywords
Unique gene patterns lead to distinct functional phenotypes and chemosensitivity profiles among subclones obtained from a single glioblastoma cell line
Sign Up to like & getrecommendations! Published in 2025 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2025091
Abstract: One of the characteristics of malignant tumors is heterogeneity, which refers to the molecular or genetic differences among progeny cells during tumor growth. This heterogeneity contributes to variations in the tumor growth rate, invasive ability,… read more here.
Keywords: cell line; functional phenotypes; tumor; gene ... See more keywords