Acid-Triggered Polymer Backbone Degradation and Disassembly to Achieve Release of Camptothecin from Functional Polyphosphoramidate Nanoparticles
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DOI: 10.1021/acsmacrolett.8b00377
Abstract: Camptothecin (CPT) is a promising anticancer drug, yet its therapeutic potential has been limited by poor water solubility and facile hydrolysis of the lactone form into an inactive carboxylate form at neutral pH. In this… read more here.
Keywords: triggered polymer; polymer backbone; acid triggered; functional polyphosphoramidate ... See more keywords