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   Articles with "functional proteomics" as a keyword



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Advanced Cell Mapping Visualizations for Single Cell Functional Proteomics Enabling Patient Stratification

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recommendations! Published in 2020 at "PROTEOMICS"

DOI: 10.1002/pmic.201900270

Abstract: Highly multiplexed single‐cell functional proteomics has emerged as one of the next‐generation toolkits for a deeper understanding of functional heterogeneity in cell. Different from the conventional population‐based bulk and single‐cell RNA‐Seq assays, the microchip‐based proteomics… read more here.

Keywords: single cell; advanced cell; functional proteomics; cell ... See more keywords

Functional proteomics reveals that Slr0237 is a SigE‐regulated glycogen debranching enzyme pivotal for glycogen breakdown

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recommendations! Published in 2024 at "PROTEOMICS"

DOI: 10.1002/pmic.202300222

Abstract: The group 2 σ factor for RNA polymerase SigE plays important role in regulating central carbon metabolism in cyanobacteria. However, the regulation of SigE for these pathways at a proteome level remains unknown. Using a… read more here.

Keywords: glycogen; debranching enzyme; proteomics reveals; reveals slr0237 ... See more keywords

Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.05.076

Abstract: piRNAs play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections. In C. elegans, piRNA precursors are transcribed in the nucleus and are subjected to a number of… read more here.

Keywords: pics complex; maturation; functional proteomics; chromosome segregation ... See more keywords
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Advances in functional proteomics to study plant-pathogen interactions.

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recommendations! Published in 2021 at "Current opinion in plant biology"

DOI: 10.1016/j.pbi.2021.102061

Abstract: Pathogen infection triggers complex signaling networks in plant cells that ultimately result in either susceptibility or resistance. We have made substantial progress in dissecting many of these signaling events, and it is becoming clear that changes… read more here.

Keywords: pathogen; plant; plant pathogen; functional proteomics ... See more keywords

Abstract 4496: Small molecule inhibition of previously “undrubbable” transcription factors with AI-guided functional proteomics

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-4496

Abstract: Transcription factors (TFs) are central regulators of gene expression and key drivers of diseases such as cancer, autoimmune disorders, neurological disease, and metabolic conditions. Despite their critical role, TFs have long been considered “undruggable” due… read more here.

Keywords: molecule; molecule inhibition; small molecule; transcription factors ... See more keywords
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A Highly Efficient Xylan-Utilization System in Aspergillus niger An76: A Functional-Proteomics Study

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recommendations! Published in 2018 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2018.00430

Abstract: Xylan constituted with β-1,4-D-xylose linked backbone and diverse substituted side-chains is the most abundant hemicellulose component of biomass, which can be completely and rapidly degraded into fermentable sugars by Aspergillus niger. This is of great… read more here.

Keywords: aspergillus niger; xylan; niger an76; efficient xylan ... See more keywords

Integrative Organelle-Based Functional Proteomics: In Silico Prediction of Impaired Functional Annotations in SACS KO Cell Model

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12081024

Abstract: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an inherited neurodegenerative disease characterized by early-onset spasticity in the lower limbs, axonal-demyelinating sensorimotor peripheral neuropathy, and cerebellar ataxia. Our understanding of ARSACS (genetic basis, protein function,… read more here.

Keywords: based functional; disease; integrative organelle; proteomics silico ... See more keywords