Reporter cell assay-based functional quantification of TNF-α-antagonists in serum -- a proof-of-principle study for adalimumab.
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DOI: 10.1016/j.ab.2020.113646
Abstract: Quantification of therapeutic antibodies is commonly based on physico-chemical assays such as enzyme-linked immunoabsorption assays (ELISA) and lately on mass spectrometry. However, the functional integrity of evaluated immunoglobulins is yet not assessed. Consequently, a commercially… read more here.
Keywords: cell assay; quantification; reporter cell; functional quantification ... See more keywords