Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump
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DOI: 10.1002/bies.202200052
Abstract: Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of… read more here.
Keywords: endoplasmic reticulum; functional regulation; structural basis; reticulum ... See more keywords
The functional anatomy of the cerebrocerebellar circuit: A review and new concepts
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DOI: 10.1002/cne.24361
Abstract: The cerebrocerebellar circuit is a feedback circuit that bidirectionally connects the neocortex and the cerebellum. According to the classic view, the cerebrocerebellar circuit is specifically involved in the functional regulation of the motor areas of… read more here.
Keywords: functional regulation; anatomy; circuit; cerebrocerebellar circuit ... See more keywords
Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells
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DOI: 10.1002/iub.1870
Abstract: The hematopoietic system has a very well‐studied hierarchy with the long‐term (LT) hematopoietic stem cells (HSCs) taking the top position. The pool of quiescent adult LT‐HSCs generated during the fetal and early postnatal life acts… read more here.
Keywords: energy; functional regulation; metabolic pathways; hematopoietic stem ... See more keywords
Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases
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DOI: 10.3389/fphar.2022.868401
Abstract: ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in… read more here.
Keywords: therapeutic strategies; katp; clinical therapeutic; katp channels ... See more keywords
Functional Regulation of PPARs through Post-Translational Modifications
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DOI: 10.3390/ijms19061738
Abstract: Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and they are essential regulators of cell differentiation, tissue development, and energy metabolism. Given their central roles in sensing the cellular metabolic state and controlling… read more here.
Keywords: ppar; functional regulation; post translational; ppars post ... See more keywords