A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201166
Abstract: Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self‐renewal and proliferation, such as Hedgehog, Notch, Wnt/β‐catenin, TGF‐β, and Myc, may be potential therapeutic targets. Here, a… read more here.
Keywords: inhibition; transcription; cancer stem; functional screening ... See more keywords
Genes affecting ionizing radiation survival identified through combined exome sequencing and functional screening
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24241
Abstract: The study of genetic syndromes characterized by sensitivity to DNA damaging agents has provided important insights into the mechanisms that maintain genome stability and identified novel targets for cancer therapies. Here, we used exome sequencing… read more here.
Keywords: dna damage; exome sequencing; ionizing radiation; functional screening ... See more keywords
Abstract 274: Mitochondrial Translation Machinery Defects Causes Cardiomyopathy and i n vivo Functional Screening of Therapeutic Targets
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DOI: 10.1161/res.125.suppl_1.274
Abstract: More than 95% of ATP consumed in the heart is derived from oxidative phosphorylation (OxPhos) in the mitochondria. Besides over a thousand proteins encoded by nuclear DNA, mitochondrial gene expression machinery generates 13 proteins for… read more here.
Keywords: heart; machinery; mrps5 deficient; vivo functional ... See more keywords