Functional segregation loss over time is moderated by APOE genotype in healthy elderly
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DOI: 10.1002/hbm.24036
Abstract: We investigated the influence of the apolipoprotein E‐ɛ4 allele (APOE‐ɛ4) on longitudinal age‐related changes in brain functional connectivity (FC) and cognition, in view of mixed cross‐sectional findings. One hundred and twenty‐two healthy older adults (aged… read more here.
Keywords: apoe genotype; functional segregation; moderated apoe; segregation ... See more keywords
Functional dedifferentiation of associative resting state networks in older adults – A longitudinal study
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DOI: 10.1016/j.neuroimage.2020.116680
Abstract: Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger functional interaction between these networks. This phenomenon has been characterized as reduced functional segregation and has been investigated mainly in… read more here.
Keywords: state; functional segregation; state networks; resting state ... See more keywords
Impact of Transcranial Direct Current Stimulation on Cognitive Function, Brain Functional Segregation, and Integration in Patients with Mild Cognitive Impairment According to Amyloid-Beta Deposition and APOE ε4-Allele: A Pilot Study
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DOI: 10.3390/brainsci11060772
Abstract: Anodal transcranial direct current stimulation (anodal-tDCS) is known to improve cognition and normalize abnormal network configuration during resting-state functional magnetic resonance imaging (fMRI) in patients with mild cognitive impairment (MCI). We aimed to evaluate the… read more here.
Keywords: apoe allele; segregation integration; functional segregation; anodal tdcs ... See more keywords