Anti-FGFR3 antibody epitopes are functional sites and correlate with the neuropathy pattern
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577757
Abstract: Antibodies against FGFR3 define a subgroup of sensory neuropathy (SN). The aim of this study was to identify the epitope(s) of anti-FGFR3 autoantibodies and potential epitope-dependent clinical subtypes. Using SPOT methodology, five specific candidate epitopes,… read more here.
Keywords: sites correlate; fgfr3 antibody; antibody epitopes; functional sites ... See more keywords
Three isoreticular MOFs derived from nitrogen-functionalized diisophthalate ligands: exploring the positional effect of nitrogen functional sites on the structural stabilities and selective C2H2/CH4 and CO2/CH4 adsorption properties
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry frontiers"
DOI: 10.1039/c8qi00268a
Abstract: Understanding the structure–property relationship is conducive to the rational design and synthesis of porous MOFs with better performance. In this work, we constructed three isoreticular MOFs derived from quinoline-functionalized bent diisophthalate ligands as a platform… read more here.
Keywords: adsorption; ch4; nitrogen functional; co2 ch4 ... See more keywords
Lanthanide metal-organic frameworks with nitrogen functional sites for the highly selective and sensitive detection of NADPH.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04152a
Abstract: A series of isostructural Ln-MOFs, namely Eu(BPDC-xN)(x = 0, 1, 2), with different numbers of nitrogen atoms were designed and synthesized. Due to the strong affinity between the bare phosphate group of NADPH and nitrogen… read more here.
Keywords: detection; highly selective; sites highly; selective sensitive ... See more keywords
Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac599
Abstract: Abstract Protein language modeling is a fast-emerging deep learning method in bioinformatics with diverse applications such as structure prediction and protein design. However, application toward estimating sequence conservation for functional site prediction has not been… read more here.
Keywords: functional sites; sequence conservation; alignment free; conservation ... See more keywords
RbgA ensures the correct timing in the maturation of the 50S subunits functional sites
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac059
Abstract: Abstract RbgA is an essential protein for the assembly of the 50S subunit in Bacillus subtilis. Depletion of RbgA leads to the accumulation of the 45S intermediate. A strain expressing a RbgA variant with reduced… read more here.
Keywords: rbga; functional sites; rbga ensures; 44s particles ... See more keywords
Effect of the sequence data deluge on the performance of methods for detecting protein functional residues
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2084-7
Abstract: BackgroundThe exponential accumulation of new sequences in public databases is expected to improve the performance of all the approaches for predicting protein structural and functional features. Nevertheless, this was never assessed or quantified for some… read more here.
Keywords: effect sequence; functional residues; sequence data; performance ... See more keywords